耐氟康唑念珠菌和耐伊曲康唑烟曲霉对泊沙康唑的敏感性测定

摘要

目的：测定耐氟康唑念珠菌和耐伊曲康唑烟曲霉临床分离株对泊沙康唑的敏感性。方法参照美国临床实验室标准化研究所制定的 M27-A3和 M38-A2方案，测定从临床获得的11株耐氟康唑的念珠菌和3株耐伊曲康唑烟曲霉对泊沙康唑的 MIC 值。结果对于氟康唑耐药的念珠菌，泊沙康唑的 MIC 范围是0.125~1μg/ mL。对于伊曲康唑耐药烟曲霉，泊沙康唑的 MIC 范围是0.06~0.5μg/ mL。结论11株耐氟康唑的念珠菌和3株耐伊曲康唑烟曲霉均对泊沙康唑有效。%Objective To determine the in vitro susceptibility of fluconazole( FLU)-resistant Candida spp. and itraconazole (ITC)-resistant Aspergillus spp. to posaconazole(POS). Methods The MICs of FLU,ITC,voriconazole(VRC)and POS were determined according to CLSI M27-A3 and M38-A2 methods in eleven isolates of Candida spp. and three isolates of Aspergillus spp. Results MICs of FLU,ITC,VRC and POS against FLU-resistant Candida spp. were 64 μg/ mL,0. 5 ~ 16 μg/ mL,0. 25 ~ 2 μg/mL and 0. 125 ~ 1 μg/ mL. And MICs of ITC,VRC and POS against ITC-resistant Aspergillus spp. were ﹥ 16 μg/ mL,1 ~ 2 μg/ mL and 0. 25 ~ 0. 5 μg/ mL. Conclusion POS is effective to FLU-resistant Candida spp. and ITC-resistant Aspergillus spp. in vitro .