Objective To investigate the correlation of plasma homocysteine ( Hcy ) level with carotid intima-media thickness ( IMT) and carotid atherosclerosis in Uygur and Han patients with hypertension living in Xinjiang Region .Methods A total of 420 essential hypertension patients admitted to Department of Geriatrics in our hospital from 2011 to 2015 were enrolled in this study .There were 214 subjects of Han nationality, at an age of (63.36 ±14.82) years, and 206 subjects of Uygur nationality, at an age of (64.16 ±15.79) years.Another 405 healthy individuals who taking physical examination in that period served as normal controls , and they were 203 of Han nationality (60.45 ±14.11 years old) and 202 of Uygur nationality (61.23 ±12.71 years old).Enzyme-linked immunosorbent assay was applied to determine the plasma level of Hcy , and color Doppler ultrasonography was applied to measure the carotid IMT.Results Compared with the normal controls , the hypertension group had higher body mass index (BMI), systolic blood pressure ( SDP) , diastolic blood pressure ( DBP) , and plasma Hcy level , but lower folic acid ( FA) , thicker carotid IMT and higher incidence of carotid plaques (P<0.05).There were no obvious differences between the Han and Uygur hypertensive patients in age , sex, uric acid (UA), triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipopro-tein cholesterol (LDL-C), FA, carotid IMT and incidence of atherosclerotic plaques (P>0.05).Plasma Hcy level was positively correlated with age, TC, LDL-C and SBP, but negatively with FA.Carotid IMT was positively correlated with age , TC, LDL-C, SBP and Hcy level, but negatively with FA.Conclusion Age, TC, LDL-C and hyperhomocysteine are risk factors of carotid atherosclerosis for Uygur and Han hypertensive patients living in Xinjiang .%目的：探讨新疆维吾尔族和汉族高血压患者血浆同型半胱氨酸（ Hcy）水平与颈动脉内膜中层厚度（ IMT）及颈动脉粥样硬化之间的关系。方法入选2011年至2015年期间在新疆医科大学第一附属医院老年病科住院的原发性高血压患者420例，入选同期入院的健康体检人群405例作为对照。依据研究对象的民族及是否患有高血压分为4组：维吾尔族高血压组（n＝206），维吾尔族对照组（n＝202），汉族高血压组（n＝214）和汉族对照组（n＝203）。采用酶联免疫吸附实验测定血浆Hcy水平，彩色多普勒超声测定颈动脉IMT。结果民族内比较结果显示，相比对照组，高血压组体质量指数（ BMI ）、收缩压（SBP）、舒张压（DBP）、Hcy水平高，叶酸（FA）水平低，颈动脉IMT增厚，粥样硬化斑块发生率高，差异均具有统计学意义（P＜0．05）。民族间比较结果显示，维吾尔族和汉族高血压患者间年龄、性别、尿酸（UA）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（ HDL－C）、低密度脂蛋白胆固醇（ LDL－C）、FA、维生素B12、Hcy水平、颈动脉IMT和粥样硬化斑块发生率差异无统计学意义（P＞0．05）。 Hcy与年龄、TC、LDL－C、SBP呈正相关，与FA呈负相关。颈动脉IMT与年龄、TC、LDL－C、SBP、Hcy呈正相关，与FA呈负相关。结论高Hcy血症、年龄、TC、LDL－C是新疆维吾尔族和汉族高血压患者颈动脉粥样硬化的危险因素。
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