目的：研究脆性组氨酸三联体( FHIT)与Survivin在上皮性卵巢癌中的表达和相互关系,以及化疗对其表达的影响。方法运用免疫组织化学( S-P法)检测FHIT与Survivin在99例卵巢组织中的表达。结果 FHIT在未化疗的上皮性卵巢癌组织中的缺表达率分别显著高于正常卵巢、良性囊腺瘤和交界性囊腺瘤等三种卵巢组织,P均<0.05；Survivin在未化疗的上皮性卵巢癌中的表达率显著高于正常卵巢、良性囊腺瘤、交界性囊腺瘤(P均<0.05)；FHIT与Survivin与病理分级和临床分期均有关(P均<0.05)；FHIT与Sur-vivin在上皮性卵巢癌中的表达呈负相关；化疗前后 FHIT 和 Survivin 的表达无明显改变(P 均>0.05)。结论 FHIT缺失与Survivin表达在卵巢癌发生发展的过程中可能存在协同作用；铂类为主的化疗可能对FHIT和Survivin的表达无明显影响。%Objective To investigate expression and relationship of FHIT and Survivin and effection of chemothera-peutics to FHIT and Survivin. Method FHIT and Survivin protein were detected by immunohistochemical ( S-P) technique in 99 cases of epithelial ovarian neoplasms, respectively. Result Expression of FHIT in unchemo epitheli-al ovarian carcinoma was significantly lower than in normal ovarian tissue, benign cystadenoma, borderline cystade-noma (P<0. 05), and expression of Survivin in unchemo epithelial ovarian carcinoma was higher (P<0. 05). Ex-pression of FHIT and Survivin among the grades and the clinical stages was significantly different (P<0. 05), there was negative correlation between FHIT expression and Survivin expression in epithelial ovarian cancer, the expres-sion of FHIT and Survivin showed no significant change (P>0. 05) in chemotherapy and unchemo epithelial ovarian carcinoma. Conclusion FHIT and Survivin may play a important roles in the tumorigenesis and development in epi-thelial ovarian cancer;chemotherapeutic have no effection to FHIT and Survivin.
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