Objective:To investigate that the melatonin (MT) could protect SD rats' cardiopulmonary tissue from the chronic intermittent hypoxia damage in the Atmospheric pressure. Methods:The 24 male, 5 weeks SD rats were randomly divided into three groups. And simulated human sleep time:8 rats were sent into the control group.And the control group rats wre fed with normal saline solution(NS) in the normal oxygen pressure ;16 experments rats were divided into two groups avergely: experiment group 1 and experiment group 2.The experiment group 1 rats wre fed with melatonin (MT) in the hyposia box; the experiment group 2 rats wre fed with normal saline solution(NS) in the hypoxia box;After 8 weeks each rat weight was recorded,the ratio of the right ventricle/left ventricle plus septum [RV/(LV+S) ],the ratio of the right ventricle/body weight(RV/ BW).And detected the Glutathione peroxidase (GSH-PX) activity, superoxide dismutase (SOD) activity, total antioxidant capacity (T-AOC) of every rat's myocardial and lung tissue.Result:The weights of experiment group 1 rats' were significantly increasing than experiment group 2' s(P＜0.05),the RV/(LV+S) and RV/BW of experiment group 1 rats' were significantly lower than experiment group 2's(P＜0.05),the glutathione peroxidase (GSH-PX) activity, superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC) of experiment group 1 rats' heart and lung tissue were significantly increasing than experiment group 2's(P＜0.05).The above indicators had no obvious difference between experiment group 1's and the control group's(P＞0.05),but the weights of the experiment group 2 were significantly lower the control group's(P＜0.05). the RV/(LV+S) and RV/BW of experiment group 2 were significantly increasing than the control group's(P＞0.05).The another indicators had significantly difference between experiment group 2's and the control group's. Conclusion:The chronic intermittent hypoxia could damage SD rats' heart and lung. Melatonin(MT)could prevent cardiopulmonary tissue from the chronic intermittent hypoxia damage.%目的:探讨褪黑素(MT)对常压下慢性间歇缺氧损伤SD大鼠心肺的保护作用.方法:将24只雄性,5周SD大鼠随机分成三组并模拟人类睡眠时间:对照组在常压常氧下饲养加灌服生理盐水,实验组分为实验1组常压低氧箱内饲养加灌服褪黑素、实验2组在常压低氧箱内饲养同时加灌服生理盐水,8周后检测体重(BW)、右心室/左心室加室间隔比值RV/(Lv+S),右心室,体质量(RV/BW)比值以及心肌和肺组织谷胱苷肽过氧化物酶(OSH-PX)活力、超氧化物歧化酶(SOD)活性、总抗氧化能力(T-AOC)的变化.结果:实验2组与实验1组比较大BW明显降低(P<0.05),而RV/(LV+S)及RV/BW明显增加(P<0.05),心肌及肺组织GSH-PX活力、SOD活性、T-AOC均明显降低(P<0.05);实验1组与对照组比较Bw无明显差异(P>0.05),而RV/(LV+s)及RV/BW无明显差异(P>0.05),心肌及肺组织GSH-PX活力、SOD活性、T-AOC均显差异(P>0.05);实验2组与对照组比较Bw明显降低(P<0.05),而RV/(LV+s)及RV/BW却增加(P<0.05),心肌及肺组织GSH-PX活力、SOD活性、T-AOC均明显差异(P<0.05).结论:褪黑素可防止慢性间歇缺氧对心肺的损伤作用.
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