基于荧光断层成像-CT双模态光源可行区选取方法

摘要

In Fluorescence Molecular Tomography (FMT), the reconstruction and fusion display of inner light source can be realized with the aid of CT data. A method is proposed in this paper to select permissible source region based on FMT image and CT data. The position and depth of light source can be estimated in FMT image. According to the coordinate relation of the two mode image, the light source position can be marked in CT data and mesh was produced on the marked CT data. Experimental results show that, the method can reduce the il-posedness of the inverse problem and improve the accuracy of reconstruction of inner light source.%在荧光断层成像（FMT）中，借助CT数据可以实现小动物体内荧光光源的重建及融合显示。该文提出了一种基于荧光断层成像CT双模态图像光源可行区的选取方法，利用多角度荧光图像估计荧光光源的位置和深度信息，然后根据双模态图像的坐标转换关系，在CT数据中设置可行区。实验结果表明，使用该方法选取光源可行区，能够有效降低逆向重建小动物体内光源的病态性，提高光源的重建精度。