安罗替尼治疗KRAS突变型晚期肺腺癌1例

摘要

近年来,晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)患者逐渐增多,治疗方法也明显增多,然而,目前对于靶向治疗表皮生长因子受体(epidermal growth factor receptor, EGFR)/间变性淋巴瘤激酶(anaplastic lymphoma kinase, ALK)耐药或化疗失败的三线及以上患者,国内外并没有标准的治疗方案,临床治疗效果也不尽如人意,安罗替尼是一种新型小分子多靶点酪氨酸激酶抑制剂,可强效抑制血管内皮细胞生长因子受体(vascular endothelial growth factor receptor, VEGFR)、血小板衍生生长因子受体(platelet-derived growth factor receptor, PDGFR)、纤维母细胞生长因子受体(fibroblast growth factor receptor, FGFR)和c-Kit等多个靶点,ALTER0303是一项关于安罗替尼作为晚期 NSCLC三线治疗方案的临床研究,结果显示安罗替尼能显著延长晚期NSCLC患者的总生存期(overall survival,OS)和无进展生存期(progression-free survival, PFS),本文报道安罗替尼治疗KRAS突变型晚期肺腺癌1例.%In recent years, the number of advanced non-small cell lung cancer (NSCLC) patients has gradually increased, and the treatment methods have also been significantly increased. However, there are no standard treatment plans at home and abroad for third-line and above patients who are refractory to targeted therapy epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) or chemotherapy. The clinical treatment effect is also not satisfactory. Anlotinib is a novel TKI targeting the vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and c-Kit. ALTER0303 trail, phase III study has demonstrated that Anlotinib significantly prolonged overall survival (OS) and progression-free survival (PFS) in advanced NSCLC patients as 3rdline treat-ment.Here we report a case of advanced lung adenocarcinoma harboring KRAS mutation treated with Anlotinib.