磁性氧化铁纳米探针用于肿瘤靶向磁共振成像的研究现状

摘要

超顺磁性氧化铁纳米粒子(SPIONs)粒径小,穿透性强,常用于制备分子成像探针或MRI对比剂.近年来,国内外对纳米修饰的肿瘤靶向性磁性氧化铁探针研究越来越多.本文对SPIONs探针的合成、表面修饰及其生物医学应用进展进行综述.%Objective Superparamagnetic iron oxide nanoparticles (SPIONs) has small size and strong penetrativity, which is often used for preparing molecular imaging probe or MR contrast agents. Recently, there are more and more domestic and overseas researches of targeted SPIONs used as probe for imaging of tumor. The synthesis of probes of SPIONs, their surface modification and biomedical application were reviewed in this article.