血浆致动脉硬化指数预测高血压病患者发生冠心病的风险

摘要

Objective To investigate the correlationship between atherogenic index of plasma (AIP) and the prevalence of coronary heart diseases in patients(pts) with essential hypertensive(EH). Methods One hundred and three hypertensive pts were categorized into two groups:Hypertension group (EH group, n = 30) and hypertension with coronary heart disease group (EH+ C HD group, n=73). Blood lipid levels were measured and ambulatory blood pressure was monitored. The levels of AIP are calculated as log[triglycerin/high density lipoprotein-cholesterol (TG/HDL -C)]. Results There were no significant difference in levels of TG, HDL -C,24 h mSBP, 24 h mDBP, 24 h mPP and 24 h mPPI in two groups. The levels of total cholesterol(TC) ,low density lipoprotein- cholesterol (LDL - C) and AIP were significantly high in EH+CHD group compared with that in EH group. Binary logistic regression analysis showed that the incidence of coronary heart diseases in pts with essential hypertension was related with the level of TG(P＜0. 05),and level of TC,LDL - C and AIP(P＜0.01). Conclusion The level of AIP was an important index to predict the risk of coronary heart diseases in pts with essential hypertension.%目的 探讨高血压病合并冠心病与血浆致动脉硬化指数(AIP)的关系.方法 入选103例高血压病住院患者,其中高血压病合并冠心病73例,高血压病无合并冠心病30例,由冠脉造影证实或有心肌梗死病史者确诊为冠心病.采血检测患者血脂水平,行24 h动态血压监测,计算AIP=log(TG/HDL-C),并行统计学分析.结果 两组患者三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及动态血压指标差异无统计学意义,而合并冠心病组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和AIP高于单纯高血压病组,差异有统计学意义(P<0.05).二分法Logistic回归分析结果表明,高血压病患者是否出现冠心病与TG相关(P<0.05),与TC、LDL-C、AIP高度相关(P<0.01).结论 高血压病合并冠心病患者AIP增加明显,AIP是高血压病患者合并冠心病的一个重要预测指标.