Objective To study the clinical significance of the serum homocysteine (Hcy) and high - sensitivity C - reactive protein (hs - CRP) in obese patients with masked hypertension (MH). Methods Seventy - eight obese patients with normal clinic blood pressure (CBP) were divided into two groups according to the result of daytime blood pressure of ambulatory blood pressure monitoring (ABPM): Obesity with MH (n=35), obesity (n=43). Thirty healthy subjects with normal weight were selected as controls. The Hcy and hs - CRP were measured and assessed in three groups. Results The 24 h SBP, 4 h DBP, dSBP, and dDBP in obesity with MH group were significantly higher than that in the other two groups (P<0. 01). The Hcy and hs - CRP in obesity with MH group were also higher than in obesity group and control group (P<0. 05 or P<0. 01). The Hcy and hs - CRP in obesity were higher than that in control group, but there were no significant difference. Conclusion There were high level of the Hcy and hs - CRP in obese patients, especially in obesity with MH. The Hcy and hs - CRP might be involved the occurrence and development process of hypertension in obese patients.%目的 探讨肥胖伴隐性高血压(MH)患者血清同型半胱氨酸(Hcy)及高敏C反应蛋白(hs-CRP)水平的变化及临床意义.方法 选取诊所血压(CBP)正常的肥胖患者78例,均行24 h动态血压(ABP)检查,按日间血压检测结果,将肥胖患者分为单纯肥胖组(肥胖组)43例和肥胖伴MH组(MH组)35例;同时选取30例体重正常的健康体检者作为对照.对比分析3组血清Hcy、hs-CRP水平.结果 肥胖组MH发病率44.87%(35/78),显著高于对照组的11.43%(P<0.01);肥胖伴MH组的24 h平均收缩压、舒张压(24 hSB、24 hDBP),日、夜平均收缩压(dSBP、dDBP)均明显高于单纯肥胖组和对照组,其血清Hcy、hs-CRP水平也显著高于单纯肥胖组(P<0.05)和对照组(P<0.01);单纯肥胖组血清Hcy、hs-CRP水平与对照组比较无统计学意义.结论 肥胖患者MH发病率显著高于对照组,其血清Hcy、hs-CRP水平也明显升高.提示血清Hcy、hs-CRP可能参与了肥胖患者并发高血压的发生、发展过程.
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