痴复康口服液结合重复性经颅磁刺激对脑卒中后前瞻性记忆障碍的影响1）

摘要

目的：探讨痴复康口服液、重复性经颅磁刺激以及二者结合治疗脑卒中后前瞻性记忆障碍的临床效果。方法将2012年3月-2013年12月我院康复科及脑病中心住院患者随机分为3组。A组(18例)：痴复康口服液加重复性经颅磁刺激治疗组；B组(20例)：痴复康口服液治疗组；C 组(20例)：阴性对照组。3组患者按上述治疗方案治疗4周。采用 Rivermead 行为记忆测试(RBMT)和剑桥前瞻性记忆测试量表(CAMPROMPT)评估患者治疗前后前瞻性记忆功能的改变。结果 A组和B组治疗后RBMT评分和CAMPROMPT评分均有提高(P<0.05)；C组治疗前后 RBMT 评分和 CAMPROMPT 评分无明显改变。治疗前3组RBMT评分和CAMPROMPT评分组间比较差异无统计学意义。治疗后3组 RBMT评分和CAMPROMPT组间比较差异有统计学意义(P<0.05),A组提高更明显。结论痴复康口服液或重复性经颅磁刺激均能改善患者脑卒中后前瞻性记忆障碍,痴复康口服液联合重复性经颅磁刺激治疗效果更明显。%Objective To explore effect of Chifukang oral liquid(COL)and repetitive transcranial magnetic stimulation therapy on prospective memory impairment post stroke.Methods All patients matched the inclusion criteria were randomly divided into 3 groups:Group A (n=18)treated with repetitive transcranial magnetic stimulation with COL,group B (n=20)treated with COL,and group C (n=20)treated with repetitive transcranial magnetic stimulation.The effects were evaluated by the Cambridge prospective memory test scale (CAMPROMPT)and Score of Rivermead Behavioral Memory Test (RBMT)before and after treatment.Results After treatment,RBMT and CAMPROMPT scores in group A and group B were improved statistically (P<0.05),comparing to that in control group.RBMT and CAMPROMPT scores were no statistically significant among the three groups before treatment (P>0.05). After treatment,the differences were statistically significant (P<0.05).Conclusion COL,repetitive transcranial magnetic stimula-tion,and combined together could improve prospective memory in patients post stroke.