冠心病室性早搏病人血小板参数的相关变化及临床意义

摘要

目的：探讨冠心病室性早搏病人血小板计数(PLT)、血小板比容(PCT)的相关变化及临床意义。方法选取中国中医科学院广安门医院2009年1月—2015年6月心血管科住院的冠心病室性早搏病人125例,24 h动态心电图(holter)记录室性早搏总数,分为Ⅰ组(<1000个)52例,Ⅱ组(1000个~10000个)53例,Ⅲ组(>10000个)20例,入院后收集病人一般情况及测定血液生化指标,比较3组间血小板参数水平。结果 PLT：Ⅲ组[(245.15±101.48)×109/L]>Ⅱ组[(199.73±74.19)×109/L]>Ⅰ组[(190.85±54.04)×109/L]组,Ⅲ组与Ⅰ组(P<0.01)、Ⅱ组(P<0.05)间差异有统计学意义。PCT：Ⅲ组(0.27±0.11)%>Ⅱ组(0.21±0.08)%>Ⅰ组(0.20±0.06)%,Ⅲ组与Ⅰ组(P<0.01)、Ⅱ组(P<0.05)间差异有统计学意义。相关性分析结果显示：室早总数与PLT(r=0.188,P<0.05)、PCT (r=0.198,P<0.05)呈正相关；室性早搏负荷与PCT (r=0.181,P<0.05)呈正相关。结论血小板计数、血小板比容的变化与冠心病室性早搏有相关性,对冠心病室性早搏的诊治及预防具有重要意义。%Objective To investigate the variation and clinical significance of platelet parameters(PLT,PCT)in patients with coronary heart disease(CHD)and premature ventricular contraction(PVC).Methods One hundred and twenty five hospitalized patients with CHD were grouped as group A(PVCs<1 000),group B(PVCs 1 000 to 10 000),group C(PVCs>10 000),according to 24 h dynamic electrocardiogram monitoring.The general information and the data of the biochemistry of serum were col ected,and the levels of platelet parameters were compared.Results PLT were 245.15± 101.48 in group C,199.73± 74.19 in group B,190.85± 54.04 in group A.The difference was statistical y significant between group C and group A or group B(P<0.05).PCT were 0.27±0.11 in group C,0.21± 0.08 in group B,0.20± 0.06 in group A.The difference was statistical y significant between group C and group A or group B(P<0.05). Correlation analysis showed that there was a positive correlation between PVCs and PLT(r=0.188,P<0.05),PCT (r=0.198,P<0.05).Conclusion PLT and PCT are related to PVCs.Clinical monitoring of the changse of PLT and PCT is important for the diagno-sis,treatment and prevention in patients with CHD and PVC.