解毒活血方对急性冠脉综合征病人炎症反应及氧化应激的影响

摘要

Objective To investigate the efficacy and mechanism of Jiedu Huoxue prescription(JHP)for treatment of acute coronary syndrome (ACS).Methods Eighty four patients with ACS were randomly divided into two groups:control group(n=42)treated with routine treatment,and treatment group(n=42)treated with JHP and routine treatment for 8 weeks.The levels of apolipoprotein B/apolipoprotein A Ⅰ (ApoB /ApoA Ⅰ),high sensitivity C reactive protein (hs CRP),interleukin 6 (IL 6),interleukin 8 (IL 8),myeloperoxidase (MPO),malondialdehyde (MDA),superoxide dismutase (SOD)were detected before treatment and after four weeks,eight weeks of treatment.Results After 8 weeks of treatment,the level of ApoB/ApoA Ⅰ in treatment group was lower than that in control group(P<0.05).After treatment,the levels of inflammatory cytokines and oxidative stress products were de-creased in two groups(P<0.05).After 8 weeks of treatment,the levels of hs CRP,IL 6,IL 8 in treatment group was lower than that in control group(P<0.05).After 4 weeks and 8 weeks of treatment,the levels of MPO and MDA in treatment group was lower than that in control group while SOD activity in treatment group was higher than that in control group(P<0.05 or P<0.01).Conclu-sion JHP can down regulate lipids,relieve inflammation and oxidative stress,improve prognosis in patients with ACS.%目的：探讨解毒活血方治疗急性冠脉综合征(ACS)的疗效及机制。方法将84例ACS病人随机分为两组，每组42例，对照组给予抗血小板凝集、血管扩张、降脂等常规西医治疗，观察组在西医治疗基础上加用解毒活血方，每日1剂，持续治疗8周，于治疗前、治疗4周、8周分别检测载脂蛋白 B/载脂蛋白 A Ⅰ(ApoB/ApoA Ⅰ)、高敏 C反应蛋白(hs CRP)、白介素6(IL 6)、白介素8(IL 8)、髓过氧化物酶(MPO)、丙二醛(MDA)、超氧化物歧化酶(SOD)变化。结果治疗8周后，观察组 ApoB/ApoA Ⅰ低于对照组(P<0.05)；治疗后两组炎症因子及氧化应激产物浓度均较治疗前降低(P<0.05)，治疗8周后观察组hs CRP、IL 6、IL 8低于对照组(P<0.05)；治疗4周、8周后，观察组MPO、MDA浓度均低于对照组，而SOD活性则高于对照组，差异有统计学意义(P<0.05或P<0.01)。结论解毒活血方可有效下调 ACS病人脂质，缓解炎症反应及氧化应激反应，改善病人预后。