冠心病痰浊证候与冠脉斑块组织学指标的相关性探讨

摘要

目的 分析中医痰浊血瘀证型与冠脉斑块组织性质层面的相关性,从而在实体斑块组织稳定性方面探索中医不同证候之间的病理生理区别.方法 采用回顾性研究,纳入行冠脉内超声(IVUS)检查的96例病人,通过测定冠脉斑块血管内腔面积(CSA)、外弹力膜面积(EEM)、斑块负荷,纤维组织面积百分比(FT％)、纤维脂质面积百分比(FF％)、钙化组织面积百分比(DC％)、坏死核心面积百分比(NC％)、斑块负荷、斑块薄纤维帽(TC FA)情况并测定相关性.结果 两组证型未观察到特异的超声组织学指标,但在观察到不同临床诊断分型中痰浊证候可能具有突出的高斑块纤维组织面积表现(P＜0.05).结论 痰浊证候病人的冠脉斑块可能具有斑块纤维组织成分丰富的特点,提示可能痰浊证型具有较稳定的冠脉斑块性质.%Objective To identify the difference of plaque components between patients with and without phlegm syndrome of Traditional Chinese Medicine (TCM) using the intravascular ultrasound (IVUS).Methods Ninety-six patients with coronary heart disease (CHD) who were underwent IVUS were observed.The cross-sectional area (CSA),extra-elastic membrane (EEM),plaque burden,percentage of fibrous tissue (FT％),percentage of fibrotic (FF％),percentage of dense calcium (DC％),percentage of necrotic core (NC％) were detected.Results There is no significantly statistical difference in CSA,EEM,plaque burden,percentage of FT％,percentage of FF％,percentage of DC;and percentage of NC between patients with and without phlegm syndrome.Patients with phlegm syndrome may have prominent high percentage of fibrous tissue (P ＜0.05).Conclusion The high FT％ in coronary plaque may be the presentation of phlegm syndrome.