扶正化瘀胶囊联合多烯磷脂酰胆碱胶囊治疗非酒精性脂肪性肝炎疗效观察

摘要

Objective:To observe the therapeutic effects of Fuzhenghuayu capsule combined with polyene phosphatidylcho-line capsule on the patients with nonalcoholic steatohepatitis. Methods:Sixty-three patients with nonalcoholic steatohepatitis were selected and divided randomly into two groups:treated group (35 patients) , therapy by Fuzhenghuayu capsule combined with polyene phosphatidylcholine capsule, and control group (28 patients), therapy by polyene phosphatidylcholine capsule a-lone. Before and after treatment for 12 weeks, the parameters of liver function, blood fat and liver fibrosis were detected for the patients of both groups. Results:The parameters of liver function, blood fat and liver fibrosis in the patients of both groups were all improved obviously after treatment compared with pretherapy (P <0. 05) . At 12 weeks of post-treatment, the improvement of liver function and blood fat in the patients of treated group had no significant difference compared with control group (P > 0. 05) . However, the decrease of liver fibrosis in the patients of treated group had a significant difference compared with control group ( P < 0. 05 ) . Conclusion:It has been suggested that Fuzhenghuayu capsule combined with polyene phosphatidylcholine capsule has the significant therapeutic effects on nonalcoholic steatohepatitis, enhances the effects of anti-liver fibrosis, and is worth further application in clinic.%目的:观察扶正化瘀胶囊联合多烯磷脂酰胆碱胶囊治疗非酒精性脂肪性肝炎的疗效.方法:将63例非酒精性脂肪性肝炎患者随机分成两组:治疗组35例和对照组28例.对照组患者采用多烯磷脂酰胆碱胶囊治疗；治疗组患者在对照组治疗的基础上加用扶正化瘀胶囊.观察两组患者治疗前及治疗12周时,肝功能、血脂及肝纤维化指标的变化.结果:两组患者治疗后的肝功能、血脂及肝纤维化指标与治疗前比较均得到明显改善(P＜0.05)；在治疗12周时,两组患者肝功能及血脂指标比较,差异无显著性意义(P＞0.05)；但治疗组患者肝纤维化指标的降低与对照组比较,差异有显著性意义(P＜0.05).结论:扶正化瘀胶囊联合多烯磷脂酰胆碱胶囊治疗非酒精性脂肪性肝炎能显著提高临床疗效,增强抗肝纤维化作用,值得临床推广应用.