牡甲化纤方治疗各种原因所致慢性肝病肝纤维化患者的临床研究

摘要

目的:评价中药牡甲化纤方对几种不同病因肝纤维化患者的临床疗效.方法:240例肝纤维化患者随机分成治疗组与对照组各120例,治疗组患者采用牡甲化纤方治疗,对照组患者口服复方鳖甲软肝片,两组均给予相应的病因治疗,以12周为1个疗程,2个疗程后判定疗效.比较两组患者治疗前后两组总有效率、肝功能、单胺氧化酶(MAO)、肝纤维化指标及对Ishak评分的影响.结果:①第24周治疗组总有效率高于对照组,差异有统计学意义(P＜0.01),但两组间相同病因所致的肝纤维化疗效比较,差异均无统计学意义(P＞0.05).②与对照组比较,治疗前及第12周治疗组患者TBil、AST、ALT、GLO、GGT差异无统计学意义(P＞0.05);第24周治疗组患者TBil、AST、ALT、GLO、GGT较低,差异有统计学意义(P＜0.05或P＜0.01).③与对照组比较,治疗前及第12周治疗组患者HA、PIIIP、ⅣC、LN、MAO差异无统计学意义(P＞0.05);第24周治疗组患者HA、PIIIP、Ⅳ-C、LN、MAO较低,与对照组比较,差异有统计学意义(P＜0.01).④治疗前两组Ishak评分差异无统计学意义(P＞0.05);第24周治疗组Ishak评分较低,差异有统计学意义(P＜0.01).结论:牡甲化纤方对肝纤维化患者有良好的临床疗效.%Objective:To evaluate clinical curative effect of MuJia HuaXian decoction on several different etiology of hepatic fibrosis.Methods:Two hundred and fourty patients were randomly divided into the treatment group and the control group,120 cases in each group.The treatment group were given Mu JiaHuaXian decoction,the control group were given Biejiaruangan tablets,two groups both given the corresponding etiological treatment.Three months a course,judging curative effect after 2 courses.Compared the difference of TCM clinical symptom score,liver function,MAO,indexes of hepatic fibrosis between two groups before treatment and after 12 and 24 weeks.Results:(1) The overall effect of treatment group was better than control group after 24 weeks,the difference was significant statistically (P ＜ 0.01),but the effects of hepatic fibrosis caused by same factors had no statistical significance (P ＞ 0.05).(2) Compared with control group,the levels of TBIL,AST,ALT,GLO and GGT were not statistically significant in treatment group before treatment and after 12 weeks (P ＞ 0.05).The difference were statistically significant after 24 weeks between two groups (P ＜ 0.05).(3) Compared with control group,the levels of HA,PIIIP,Ⅳ C,LN,MAO were not statistically significant in treatment group before treatment and after 12 weeks (P ＞ 0.05).(4) Compared with control group,the scores of Ishak stage were not statistically significant in treatment group before treatment (P ＞ 0.05).The difference were statistically significant between two groups after 24 weeks (P ＜ 0.01).The difference were statistically significant after 24 weeks between two groups (P ＜ 0.01).Conclusion:The MuJia HuaXian decoction had good clinical effect on patients with liver fibrosis caused by various reasons.