Objective To observe the effect of evidence-based nursing combined with targeted nursing on rehabilitation of children with hand, foot and mouth disease complicated with encephalitis. Methods One hundred and eight children with hand, foot and mouth disease and encephalitis who were treated in Xiaoyi People's Hospital from February 2015 to August 2017 were selected. The time node was May 2016, 58 children who were treated from February 2015 to April 2016 were selected as a single nursing group, and 50 children who were treated from May 2016 to August 2017 as a combined nursing group. The single nursing group adopted targeted nursing; while the combined nursing group adopted evidence-based nursing on the basis of the single nursing group. Flow cytometry was used to detect the level of white blood cell count (WBC) in cerebrospinal fluid (CSF); enzyme-linked immunosorbent assay (ELISA) was used to determine the content of CSF protein; high performance liquid chromatography (HPLC) was used to detect the content of CSF glucose (Glu); and the rehabilitation effect, complication rate, family satisfaction and hospitalization time of the two groups were observed. Results The levels of WBC, protein and Glu in CSF of the two groups were lower than those before treatment, and the above indexes in the combined nursing group were significantly lower than those in the single nursing group [WBC (×106/L): 16.98±5.76 vs. 32.53±10.74, protein content (g/L): 0.29±0.06 vs. 1.02±0.14, Glu (mmol/L): 3.26±0.28 vs. 4.69±0.51, all P < 0.05]. Compared with the single nursing group, the hospitalization time of the children in the combined nursing group was significantly shortened (days: 8.2±2.2 vs. 14.6±3.1), the total effective rate of rehabilitation and family satisfaction were significantly increased [total effective rate of rehabilitation:94.00% (47/50) vs. 75.86% (44/58), family satisfaction: 98.00% (49/50) vs. 91.38% (53/58), P < 0.05], and the incidence of complications was significantly reduced [6.00% (3/50) vs. 27.59% (10/58), P < 0.05]. Conclusion Evidence-based nursing combined with targeted nursing can improve the treatment efficiency of children with severe hand, foot and mouth combined with encephalitis, reduce the incidence of complications, speed up recovery and enhance the confidence of patients' families.%目的 观察循证护理联合针对性护理对手足口病合并脑炎危重症患儿康复效果的影响.方法 选择2015年2月至2017年8月在孝义市人民医院接受治疗的手足口病合并脑炎患儿108例,以2016年5月为时间节点,2015年2月至2016年4月收治的58例患儿为单一护理组,2016年5月至2017年8月收治的50例患儿为联合护理组.单一护理组采用针对性护理;联合护理组在单一护理组基础上采用循证护理.采用流式细胞术检测患儿治疗前后脑脊液白细胞计数(WBC)水平;采用酶联免疫吸附试验(ELISA)测定患儿治疗前后脑脊液蛋白含量;采用高效液相色谱法(HPLC)检测患儿治疗前后脑脊液葡萄糖含量;并观察两组患儿康复效果、并发症发生率、家属满意度及住院时间.结果 两组治疗后患儿脑脊液中WBC、蛋白及葡萄糖含量均较治疗前降低,且联合护理组治疗后上述指标均明显低于单一护理组〔WBC(×106/L):16.98±5.76比32.53±10.74,蛋白含量(g/L):0.29±0.06比1.02±0.14,葡萄糖含量(mmol/L):3.26±0.28比4.69±0.51,均P＜0.05〕.与单一护理组比较,联合护理组患儿住院时间明显缩短(d :8.2±2.2比14.6±3.1),康复总有效率和家属满意度均明显升高〔康复总有效率:94.00%(47/50)比75.86%(44/58),家属满意度:98.00%(49/50)比91.38%(53/58),均P＜0.05〕,并发症发生率显著降低〔6.00%(3/50)比27.59%(16/58),P＜0.05〕.结论 循证护理联合针对性护理能提高重症手足口病合并脑炎患儿的治疗有效率,减少并发症发生率,加快恢复速度,增强患者家属的信心.
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