Objective To investigate the therapeutic effects of sodium ferulale. sine eta and rhubarb on cases with acute paraquat intoxication. Methods Seventy-five cases with acute paraquat intoxication were randomly divided into two groups ; the treatment group (38 cases) and control group (37 cases). The two groups were treated with hemoperfusion (HP) and conventional treatment. The control group was treated with clay, mannitol. etc. The treatment group was given sodium femlate, srnecta and rhubarb. The incidences of gastrointestinal, lung, kidney, liver. and myocardial damages, severity scores of organ damages, the time of poison clearance, the duration of hospital stay and mortality were compared between the two groups. Results Compared with the control group, the incidences of damage in various organs in treatment group were decreased obviously (gastrointestinal : 34.2% vs. 59.4%, lung ; 42.1% vs. 67.6%. kidney ; 23.7% vs. 43.2%, liver ; 47.4% vs. 70.3%, myocardial : 21.0% vs. 43.2%. all P＜0.05). The number of the patients with damage score 2 in severity was significantly less in treatment group than that in control group (gastrointestinal : 4 vs. 13, lung :3 vs. 11, kidney : 3 vs. 10, liver : 5 vs. 13, myocardial : 2 vs. 9. all P＜0.05). The time of poison clearance in gastrointestinal tract (hours) and hospital slay (days) in treatment group were obviously shorter than those in the control group (poison clearance lime : 5.23+2.47 vs. 11.21 + 3.31. hospital stay : 10.01 + 0.75 vs. 10.76 + 1.92, all P＜0.05) and mortality was significantly lower in the treatment group (10.5% vs. 29.7%, P＜ 0.05). Conclusions Sodium ferulate. srnecta and rhubarb in combination for treatment of cases with acute paraquat intoxication has significant protective effects on multiple organ damages, the time for clearance of poison and duration of hospitaiization were shortened and the mortality was decreased.%目的 观察阿魏酸钠、思密达、大黄联合应用对急性百草枯中毒的治疗作用.方法 将确诊的75 例急性百草枯中毒患者按随机数字表法分为治疗组(38 例)和对照组(37 例),两组均行血液灌流(HP )及常规治疗,对照组给予黏土、甘露醇等;治疗组给予阿魏酸钠、思密达、大黄粉.比较两组胃肠、肺、肾、肝、心肌损伤的发生率和器官损伤严重程度评分,以及毒物清除时间、住院时间和病死率.结果 治疗组各器官损伤发生率均较对照组明显降低(胃肠:34.2% 比59.4%,肺:42.1% 比67.6%,肾:23.7% 比43.2%,肝:47.4% 比70.3%,心肌:21.0% 比43.2%,均P＜0.05)各器官损伤严重程度评分为2 分的患者例数较对照组明显减少(胃肠:4 比13,肺:3 比11,肾:3 比10,肝:5 比13心肌:2 比9,均P＜0.05),胃肠道毒物清除时间(h)、住院时间(d)均较对照组明显缩短(毒物清除时间:5.23±2.47 比11.21±3.31,住院时间:10.01±0.75 比10.76±1.92,均P＜0.05),病死率明显降低(10.5% 比29.7%,P＜0.05).结论 阿魏酸钠、思密达、大黄联合治疗对急性百草枯中毒致多器官损伤有明显的保护作用,可缩短毒物清除时间和住院时间,降低患者病死率.
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