The majority of patients have experienced pain or discomfort associated with surgery or mechanical ventilation in intensive care unit (ICU), and the use of analgesic drugs can relieve patients' anxiety, improve sleep, promote the disease recovery, reduce the use of sedative drug dosage and the occurrence of delirium. Because of less adverse reactions of the non opioid analgesic drugs, in recent years gradually the doctors in ICU have paid attention to them. In this study, the related literatures have been reviewed to realize the present situation of applying non opioid analgesic drugs in ICU. It was found that nowadays the application of commonly used non opioid drugs in ICU (including ketamine, non-steroidal anti-inflammatory drugs, tramadol, lidocaine, tramadol and gabapentin) can all decrease the use of sedative drugs and opioids, reduce the incidence of adverse reactions, and gradually they will obtain more and more attention.%重症加强治疗病房(ICU)中患者多数经历着疼痛或不适,与手术、机械通气相关,镇痛药物的使用可缓解患者焦虑情绪,改善睡眠,促进病情恢复,减少镇静药物使用剂量和谵妄的发生.非阿片类镇痛药物因其不良反应小近年来逐渐受到ICU医生的关注.本文通过文献学习,了解非阿片类镇痛药物在ICU中应用的现状,发现目前ICU中常用的非阿片类镇痛药物(包括氯胺酮、非甾体类抗炎药、曲马多、利多卡因及加巴喷丁等)均能减少镇静药物及阿片类镇痛药物的应用,降低不良反应的发生,将会受到越来越多的关注.
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