Improvement of Quality of Life with Shenfu Injection (参附注射液) in Non Small Cell Lung Cancer Patients Treated with Gemcitabine plus Cisplatin Regimen

摘要

Objective:To observe the effect of Shenfu injection(参附注射液,SFI)in treating non smallcell lung cancer(NSCLC)patients on quality of life with gemcitabine(GEM)plus cisplatin(GP)regimen.Methods:Thirty—four patients were ready to receive GP regimen chemotherapy for treating NSCLC disease,according to lot-drawing,they were divided into SFI pre-treatment group(18 cases)and SFI post-treatmentgroup(16 cases).SFI pre-treatment group:During the first treatment course,chemotherapy was begun withSFI 60 ml.intravenous dripping on the 3 rd day,once daily,consecutively fOr 10 days;on the 1st day,GPregimen(GEM 1250 mg/m2,intravenous dripping,on the 1st and 8th day;cisplatin 70 mg/m2 on the 2ndday:21 days as one cycle)was carried out;in the second treatment course GP regimen was merely given toserve as the self-control.SFI post-treatment group:the medicament sequence order was reversed from thatof pre-treatment group.Using dual international quality of life(QOL)scores,the effect of SFI on the patientsQOL was observed through random ized self pre—and post—crossover control.Results:The QOL in the 34 pa-tients after being treated bv SFI in combination with GP chemotherapy regimen in one group,and GP chemotherapy regimen alone in the other.was improved in different degrees,with significant difference(P<0.01);comparision of SFI combined with GP chemotherapy regimen with GP chemotherapy alone showedthat QOL in patients was significantly different(P<0.01).Conclusion:SFI could improve QOL in patientswith NSCLC who were treated with GP regimen.