羟基磷灰石负载放射性18F作为分子影像纳米探针在生物医学中的应用

摘要

采用简便有效的方法,制备了生物兼容性强、放射性标记羟基磷灰石(HAp)纳米粒子的正电子发射计算机断层显像(PET)纳米探针.在合成HAp纳米粒子的过程中,放射性的18F作为掺杂剂,占据HAp晶格中羟基位置,在短时间内牢固地标记到HAp上.18F不仅标记在纳米粒子的表面,而且还通过强的化学键标记在纳米颗粒的内部.以达到提高标记量并防止辐射泄漏的目的.设计的高标记量的放射性纳米探针应用于动物实验并靶向到达脏器器官.%Biocompatible and radiolabeled hydroxyapatite nanoparticles (HAp NPs) as positron emission tomography (PET) nanoprobes were developed by a facile and effective method.Radioactive 18F was firmly incorporated in the process of synthesis HAp as dopant by occupying hydroxyl vacancy in lattice of HAp in a short time.18F was not only on the surface of the HAp NPs but also inner by strong chemical bond to achieve the purpose of large amounts of labelling and prevent radiation leakage.The designed high load of radiolabeled HAp NPs was applied to animal experiment and targeted to viscera organs.