草酸钙的结晶动力学及不同种类羧酸盐的影响

摘要

通过检测体系中游离Ca2+离子浓度及草酸钙(CaOxa)的粒径随时间的变化,研究了CaOxa的结晶动力学及3种羧酸盐对CaOxa结晶动力学的影响,这些羧酸盐为:一元羧酸盐甘氨酸钠(NaGlu)、二元羧酸盐酒石酸钠(Na2Tart)和三元羧酸盐柠檬酸三钠(Na3Cit).在生理盐水中CaOxa的结晶动力学方程为r=kc3.3±0.36,平均反应速率常数(-k)为(3.1±1.8)×109;3种抑制剂对k的影响程度从大到小为:Na3Cit＞Na2Tart＞NaGlu,但其平均反应级数(-α)相差不大,-α=3.2±0.1.Na3Cit 、Na2Tart可抑制CaOxa晶体的生长和聚集过程,是潜在的肾结石抑制剂.%The kinetics of calcium oxalate (CaOxa) crystallization and the effect of three carboxylates were studied by determining the changes of free Ca2+ ions concentration and the size of CaOxa crystallites with the reaction time. These carboxylates were monocarboxylic acid salt (NaGlu), dicarboxylie-acid salt (Na2Tart), and tricarboxylic acid salt (NajCit), respectively. The dynamics equations of calcium oxalate crystallization in normal saline was r=Ac33±0.3, the average reaction rate constant (k) was (3.1±1.8)×l09. The effect of three inhibitors on k values was in the order from large to small: Na3Cit>Na2Tart>NaGlu>blank. However, there is little difference for the average reaction order (a) value and α =3.2 ±0.1. Since Na3Cit and Na3Tart can inhibit the growth and aggregation of CaOxa crystals, they may be potential inhibitors for formation of kidney stones.