由蒽醌衍生的二价和三价过渡金属偶氮配合物及其致突变-畸变作用

摘要

制备了4-(5 ′-氨基萘-3′-磺酸)偶氮-(2″-N-(4″′6″′-二氯-S-三嗪)苯-5″-(β-羟乙基砜硫酸酯)-2-甲基蒽醌(2a),4-(2′-氨基苯磺酸)偶氮-(2″-N-(4″′,6″′-二氯-S-三嗪)-3″-苯磺酸)-2-甲基蒽醌,4-(5′-氨基萘-3′-磺酸)偶氮-(2″-N-(4″′,6″′-二氯-S-三嗪)苯-5″-(β-羟乙基砜硫酸酯)-2-甲基蒽醌和4-(p-(β-羟乙基砜硫酸酯)偶氮-(2″-N-(4″′,6″′-二氯-S-三嗪)萘-5″-磺酸)-2-甲基蒽醌的FeⅢ,CoⅡ金属配合物,并在安姆/沙门氏菌/微粒体致突变试验(Ames/Salmonella/Microsome Test)和大鼠胚胎中测定其致突变-畸变作用.不管是否使用代谢赋活剂S9mix,2a-Fe和2a-Co对TA98 and TA100菌株均无致突变-畸变作用.%4-(5′-aminonaphtalene-3′-sulfonic acid)azo-(2″-N-(4″′,6″′-dichloro-S-triazine) benzene-5″-(β-sulfatoethyl sulfonyl)-2-methyl anthraquinone (2a),4-(2′-aminobenzenesulfonic acid)azo-(2″-N-(4″′,6″′-dichloro-S-triazine)-3″-benzensulfonic acid)-2-methyl anthraquinone,4-(5′-aminonaphtalene-3′-sulfonic acid)azo-(2″-N-(4″′,6″′-dichloroS-triazine)benzen-5″-(β-sulfatoethyl sulfonyl)-2-methyl anthraquinone and 4-(p-(β-sulfatoethyl sulfonyl) azo-(2″-N-(4″′,6″′-dichloro-S-triazine) naphtalene-5″sulfonic acid)-2-methyl anthraquinone with FeⅢ,CoⅡ metal complexes were prepared and used for determination of mutagenic and teratogenic effects in Ames/Salmonella/Microsome Test and in embryos of rats.2a-Fe and 2a-Co were not mutagenic for both TA98 and TA100 strains with and without metabolic activator S9mix.