大环超分子二(三环己基锡)吡啶-二甲酸酯的合成、结构和抗癌活性

摘要

Four bis(tricyclohexyltin)pyridinedicarboxylates,{[(2,6-Hpydc)SnCy3] ·MeOH}n (1),[(2,6-pydc)Sn2Cy6 (H2O)] ·PhH (2),[(3,5-pydc)Sn2Cy6(MeOH)]· MeOH (3) and [(3,5-pydc)Sn2Cy6(H2O)]·EtOH (4),have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide with 2,6-H2pydc and 3,5-H2pydc (H2pydc=pyridinedicarboxylic acid),respectively.Compounds 1～4 have been characterized by elemental,IR,(1H,13C and 119Sn) NMR and single crystal X-ray diffraction analyses.The distorted tetrahedral and trigonal bipyramid geometry is formed by the tin and ligand atoms.These compounds has a 2D network with macrocyclic supramolecular by the hydrogen bonding interaction of the neighboring molecule.The antitumor activity showed that compounds 1 and 3 have higher activities than cisplatin in HT-29,HepG2,MCF-7,KB and A549 cell line in vitro.%在微波溶剂热中,三环己基氢氧化锡分别与2,6-H2pydc和3,5-H2pydc(H2pydc=吡啶二甲酸)反应,合成了4个二(三环己基锡)吡啶-二甲酸酯:{[(2,6-Hpydc)SnCy3]·MeOH)n(1)、[(2,6-pydc)Sn2Cy6(H2O)] ·PhH (2)、[(3,5-pydc)Sn2Cy6(MeOH)]·MeOH (3)和[(3,5-pyde)Sn2Cy6(H2O)]· EtOH (4).对它们的组成和结构进行了元素分析、IR、(1H,13C和119Sn)NMR和单晶X射线衍射表征.化合物中心锡与配基原子构成畸形四、六面体构型,由于氢键作用,化合物形成二维大环网状超分子结构.初步探索了1、3对入结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)的增殖抑制活性,结果表明化合物具有广谱和较强的抗癌作用.