Objective:To analyze the nuclear proliferation in breast cancer tissue related antigen (Ki-67) and proliferating cell nucleus antigen ( PCNA ) expression changes and the relationship between breast cancer and its relationship to breast cancer chemotherapy sensitivity, provide theoretical basis for clinical effective chemotherapy of breast cancer.Methods: Subjects from our hospital in recent years,by clinical examination,84 cases of patients diagnosed with breast cancer,breast cancer tissue were measured with immunohistochemical method of Ki-67 and PCNA content, compared different Ki-67 and PCNA expression levels of patients undergoing chemotherapy curative effect difference.Results:Ki-67 positive cases for 52 cases,PCNA positive cases of 62 cases.Ki-67 positive rate and the patients with lymph node metastasis and tumor classification stage were positively correlated,the difference was sta-tistically significant,P<0.05).The PCNA positive rate and the tumor was closely relative to lymph node metastasis,P<0.05,has nothing to do with tumor clinical classification stage(P>0.05).The total effective rate of Ki-67+was significantly higher than that of Ki-67-(80.8%and 56.2%,P<0.05).Effective rate of PCNA-significantly higher than that of PCNA+(72.7% to 45.2%,P<0.05).Conclusion:Ki-67 clinical data and PCNA expression is closely related to breast cancer and chemotherapy sensitivity.It can be used as a prediction index of curative effect of chemotherapy.%目的：探讨分析乳腺癌组织中核增殖相关抗原（Ki-67）及增殖细胞核抗原（PCNA）表达变化与乳腺癌的关系及其对乳腺癌化疗敏感性的关系，为临床乳腺癌的有效化疗提供理论依据。方法：实验对象取自于近年来我院收治的、经临床检查确诊为乳腺癌患者84例，利用免疫组化方法分别测量其乳腺癌组织中的Ki-67及PCNA的含量，比较不同Ki-67及PCNA表达水平的患者接受化疗疗效的差异。结果：Ki-67阳性例数为52例，PCNA阳性例数为62例。 Ki-67阳性率与患者淋巴结转移及肿瘤分型分期呈正相关，差异有统计学意义，P＜0.05。而PCNA阳性率与肿瘤淋巴结转移成正相关，P＜0.05，与肿瘤临床分型分期无关，P＞0.05。 Ki-67＋总有效率为80.8％明显高于Ki-67-的56.2％，P＜0.05。 PCNA-有效率为72.7％明显高于PCNA＋的45.2％，P＜0.05。结论：Ki-67及PCNA表达与乳腺癌临床资料及其化疗敏感性密切相关，可以作为预测化疗疗效的指标。
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