曲唑酮联合低剂量西地那非对早泄合并勃起功能障碍患者的疗效及安全性分析

摘要

Objectives:To observe the efficacy and safety analysis of trazodone combined low dose of silde-nafil treatment on patients with ED and PE.Methods:87 patients with erectile dysfunction and premature ejacula-tion,from March 201 0 to March 201 1 ,were selected and randomly divided into observation group and control group.Observation group was given trazodone combined with low doses of sildenafil treatment;control group was on-ly given trazodone treatment.Results:IIEF-5 score of the observation group and control group increased signifi-cantly after treatment.The observation group’s (1 9.5 ±2.3)points were significantly higher than that of control group (1 6.1 ±3.5);the LELT time of observation group was significantly higher than that of control group,which were (5.2 ±0.4)min and (2.9 ±0.1 )min respectively.Effective rate of PE treatment in observation group was 95 .5%,which was significantly higher than the control group of 81 .4%;effective rate of ED treatment in observa-tion group was 93.2%,which was significantly higher than the control group of 79.1%.Adverse reactions rate was 22.7% in the observation group and 20.9% in the control group,and differences in blood pressure,serum creati-nine,blood,cyclosporine A and other indicators between the two groups were not significantly significant.Conclu-sion:Trazodone combined low dose of sildenafil is of significantly high efficacy and safety in the treatment on pa-tients with ED and PE.%目的：观察分析曲唑酮联合低剂量西地那非对 PE 合并 ED 患者的疗效及安全性分析。方法：选取2010年3月至2011年3月收治的早泄合并勃起功能障碍的患者共87例。随机将患者分为观察组和对照组，其中观察组患者采用曲唑酮联合低剂量的西地那非；对照组患者单纯采用曲唑酮。结果：观察组和对照组两组患者接受治疗后IIEF－5的评分有明显上升，其中观察组为（19．5±2．3）分，明显高于对照组的（16．1±3．5）分；而观察组患者的LELT时间均明显要高于对照组，分别是（5．2±0．4）min 和（2．9±0．1）min。观察组患者的PE治疗有效率为95．5％，明显要高于对照组的81 ．4％；而观察组的ED治疗有效　　率为93．2％，明显比对照组的79．1％要高。观察组患者的不良反应发生率为22．7％，对照组为20．9％；两组患者的血压、血肌酐、血环孢素A等指标对比没有显著性差异。结论：曲唑酮联合低剂量西地那非对PE合并ED有显著的疗效和较高安全性。