早期上皮卵巢癌保留生育功能手术临床分析

摘要

Objectives:To investigate the efficacy and safety of fertilitysparing surgery at early stage of epithelial ovarian cancer (EOC).Methods:The clinical data of 60 patients at stage I EOC received fertilitysparing surgery from January 2004 to December 2014 (conservative group) and that of 100 patients received radical surgery (radical group) during the same period were selected to analyze the clinical efficacy and safety.Results:Difference in the 5 years' survival rate (83.33％,80.00％) and survival rate without tumor (80.00％,78.00％) between conservative group and radical group was not statistically significant (P ＞ 0.05).In the conservative group,the 5 years' recurrence rate and 5 years' survival rate of high differentiation patients were both high,but those of low differentiation patients and patients with clear cell carcinoma were low.After treatment,70.00％ of patients had abnormal menstruation which returned to normal after chemotherapy,and 75％ of patients had successful delivery with healthy and normal newborns.Conclusion:Fertilitysparing surgery is safe and effective for patients at early stage of epithelial ovarian cancer,which is suggested for young patients with fertility requirements.%目的:探讨早期上皮卵巢癌保留生育功能手术的疗效和安全性.方法:收集从2004年1月至2014年12月在我院接受早期上皮卵巢癌保留生育功能手术的60例患者(保守组)及100例行根治手术患者(根治组)的临床治疗资料,分析该手术的临床疗效及其安全性.结果:保守组和根治组5年生存率(83.3％和80.0％)及无瘤生存率(58.3％和57.0％)之间的比较均无显著性差异(P＞0.05);保守组高分化癌患者术后5年复发率及存活率均高,低分化和卵巢透明细胞癌较低;术后化疗70.0％患者出现月经异常,化疗结束后恢复正常;术后75.0％患者成功分娩,子代健康,无畸形.结论:早期上皮卵巢癌患者实施保留生育功能手术具有一定的安全性和疗效,对于有生育要求的、年轻的早期上皮卵巢癌患者值得尝试.