中频穴位电刺激联合他达拉非治疗糖尿病性勃起功能障碍的疗效观察

摘要

Objectives:To investigate the clinical efficacy and safety of moderate-frequency electrical pulse acupoint stimulation (EPAS) in treatment of diabetic erectile dysfunction (DED).Methods:90 diabetic men with DED were randomly divided into observation group and control group,with 45 cases in each group.Control group were instructed to use tadalafil (5mg/day) only,whereas observation group were treated with combination therapy,including tadalafil 5 mg and EPAS.The courses of treatment were 4 weeks in both groups.Curative efficacies,changes of the International Index of Erectile Function (IIEF-5),serum testosterone levels (T) before and after treatment,and adverse reactions during treatment of both groups were compared.Results:The patients in each group all showed remarkable increase in IIEF-5 scores.IIEF-5 scores in observation group after treatment were statistically higher than that of control group (P ＜ 0.05).Testosterone in observation group after treatment were statistically higher than that of control group (P ＜ 0.05).No severe adverse reaction occurred in both groups.Conclusion:The moderate-frequency electrical pulse acupoint stimulation combined with tadalafil therapy can significantly enhances the treatment effect,which is worth of being widely applied in clinical practice.%目的:探讨中频穴位电刺激联合他达拉非治疗糖尿病性勃起功能障碍(DED)的临床疗效.方法:将90例糖尿病性勃起功能障碍患者,随机分为试验组和对照组各45例,对照组给予他达拉非片5mg口服,每晚1次,4周为1疗程.试验组在对照组治疗的基础上加用中频穴位电刺激4周;比较两组患者治疗疗效、治疗前后勃起功能国际指数问卷(IIEF-5)评分、血清睾酮水平变化及治疗期间不良反应发生情况.结果:试验组总有效率高于对照组(P＜0.05),两组IIEF-5评分明显增加(P＜0.05),试验组IIEF-5评分治疗后高于对照组(P＜0.05),两组血清睾酮水平有不同程度提高(P＜0.05),试验组血清睾酮水平治疗后高于对照组(P＜0.05),两组患者均未见严重不良反应.结论:中频穴位电刺激联合小剂量他达拉非治疗糖尿病性勃起功能障碍比单独药物治疗所取得的临床疗效更安全可靠,值得临床推广.