轻度认知障碍患者认知功能与事件相关电位N400的临床研究

摘要

目的 探讨轻度认知障碍(mild cognitive impairment,MCI)患者的认知功能状况与N400表现.方法 选择MCI患者20例(MCI组),健康体检者23例(对照组).使用简易智能状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)对所有受试者进行评定,并做N400检测,分析它们之间的相关性及对MCI的诊断价值.结果 与对照组比较,除MoCA语言项外,MCI组MMSE、MoCA评分明显降低,差异有统计学意义(P＜0.05,P＜0.01);N400潜伏期延长,其中Fz、Pz匹配和非匹配刺激潜伏期,C3、C4非匹配刺激潜伏期,Pz、C4匹配刺激波幅的差异有统计学意义(P＜0.05,P＜0.01).N400潜伏期与MMSE总分、MoCA总分呈负相关,N400波幅与MMSE总分、MoCA总分呈正相关(P＜0.05,P＜0.01).结论 MCI患者存在N400的异常及认知功能的损害,N400对MCI的诊断具有辅助价值.%Objective To explore the cognitive function and event-related potential N400 in patients with mild cognitive impairment (MCI). Methods Twenty patients with MCKMCI group) and 23 normal controls (control group) were investigated. All subjects were assessed with mini-mental state examination(MMSE) and Montreal cognitive assessment score(MoCA) and event-related potential N400 measurement. The correlation between cognition and event-related potential N400 was analyzed and its diagnostic value for MCI was evaluated. Results The scores of MMSE and MoCA were significantly lower in MCI group than in control group (P < 0. 05, P < 0. 01). N400 latency was significantly longer in MCI group than in control group (P < 0. 05,P < 0. 01). N400 amplitude was significantly lower in MCI group than in control group (P < 0. 05). The latency and amplitude of N400 significantly correlated to the scores of MMSE and MoCA. Conclusion The findings suggest that MCI patients have impairment in their cognitive function and N400. Event-related potential N400 is valuable in the diagnosis of MCI.