内镜下均一胃黏膜颗粒样改变的临床特征及治疗效果分析

摘要

Objective To investigate the clinical and pathologic characteristics of gastric mucosal nodular changes and analyze the merits of treatments for optimizing the measures for the disease.Methods Clinical manifestation, pathological manifestation, H.pylori infection rate, bile reflux endoscopic detection rate were compared between gastric mucosal nodular changes and common chronic atrophic gastritis.Clinical characteristics of gastric mucosal nodular changes were analyzed.One hundred and twenty-seven cases of gastric mucosal nodular changes who underwent endoscopic examination were divided into three groups according to the treatment methods.Pure proton pump inhibitors, quadruple eradication H.pylori, proton pump inhibitors with bile reflux medication were used in patients with gastric mucosal nodular changes, and the treatment effect was compared.Results The incidence rates of abdominal pain, distention, heartburn in gastric mucosal nodular changes group were higher than those in control group (P<0.05).The incidence rate of intestinal metaplastia in the pathological results in 127 cases of gastric mucosal nodular changes was significant different than that in control group (P<0.05).The incidence rate of bile regurgitation was higher than that in control group (P<0.05).Conclusion As a special gastritis, the patients with gastric mucosal nodular changes have particular clinical symptoms.The eradication of H.pylori is a very outstanding method to treat the disease.%目的 探讨内镜下均一胃黏膜颗粒样改变的临床及病理特点,分析各种药物的治疗效果.方法 通过对比胃黏膜颗粒样改变与普通慢性非萎缩性胃炎的临床表现、病理表现、H.pylori感染率、胆汁反流内镜检出率等分析胃黏膜颗粒样改变的临床特点.127例接受过内镜检查的胃黏膜颗粒样改变患者按治疗方式的不同分为三组,分别采用单纯质子泵抑制剂、质子泵抑制剂为主的四联根除H.pylori、质子泵抑制剂加抗胆汁反流药物治疗,并比较各组治疗效果.