临床实践指南制订方法——GRADE方法理论篇

摘要

科学的证据分级与推荐强度对指南的制订、实施具有重要意义.证据是循证医学的核心,GRADE证据质量分级和推荐强度系统是证据发展史上的里程碑事件.本文从GRADE方法的发展,基本概念与原理,应用范围及工具等理论方面系统的介绍GRADE.%Scientific evidence grading and recommendation intensity are of great significance for the development and implementation of the guidelines.Evidence is the core of evidence-based medicine, and the GRADE evidence quality grading and recommendation intensity system is a milestone in the history of evidence development.This article introduces GRADE from the development of the GRADE method, the basic concepts and principles, the scope of application and the theoretical aspects of the tools.