勃起功能障碍与糖尿病患者冠心病风险相关性的Meta分析

摘要

目的：系统评价糖尿患者群中勃起功能障碍（ED）与冠状动脉粥样硬化性心脏病（CHD，冠心病）发病风险关系。方法检索PubMed、Embase、中国知网、中国生物医学文献数据库及万方数据库中公开发表的探讨ED与CHD发病风险关系的观察性研究，对符合纳入标准的文献提取数据，采用CMA v2软件进行Meta分析。结果最终纳入3个队列研究、1个病例-对照研究和9个横断面研究。Meta分析结果显示，与单纯糖尿病相比，同时患有ED的人群罹患CHD的风险显著增加（队列研究：RR=1.72，95%CI：1.50~1.98，P＜0.01；病例对照和横断面研究：OR=3.07，95%CI=2.05~4.59，P＜0.01），敏感性分析显示结果稳健性好。结论糖尿病合并ED患者CHD风险显著增加，但ED是糖尿病患者群的危险因素还是仅为标记物仍待进一步研究。%Objective To review systematically the correlation between erectile dysfunction (ED) and risk of coronary heart disease (CHD) in diabetic patients. Methods The databases of PubMed, Embase, CNKI, CBM and WanFang Database were retrieved for collecting the published observation studies on the correlation between ED and CHD risk. The data was extracted from eligible literature and given a Meta-analysis by using CMA v2 software. Results There were finally 3 cohort studies, 1 case-control study and 9 cross-sectional studies included. The results of Meta-analysis showed that CHD risk significantly increased in diabetic patients with ED (cohort studies:RR=1.72, 95%CI:1.50-1.98, P<0.01, and case-control and cross-sectional studies:OR=3.07, 95%CI:2.05~4.59, P<0.01). Sensitivity analysis showed the results were stable. Conclusion CHD risk significantly increases in diabetic patients with ED, while further studies are necessary to explore whether ED is a risk factor or just a marker.