Objective To discuss the changes of telomere length of peripheral white blood cells (PWBC) in patients with premature coronary artery disease (PCAD). Methods The patients (n=80, male 43 and female 37) hospitalized in the Department of Cadre Healthcare of Qingdao Municipal Hospital were chosen as case group from Jan. 2010 to Nov. 2011. The case group was divided, according to Gensini integrals, into group A, group B, group C and group D, and also divided, according to disease extent, into 1-vessel group, 2-vessel group and multi-vessel group. At the same time, other 76 cases with examinations of coronary angiography (CAG) or coronary CTA for excluding CHD were chosen as control group. The changes of biochemical indexes, blood pressure (BP) and ratio of telomere length (T/S) were detected in all groups. Results T/S was (0.87±0.31) in case group and (1.12±0.25) in control group, which indicated that telomere length of PWBC was significantly shorter in case group than that in control group (P<0.05). T/S was (0.89±0.41) in group A, (0.91±0.32) in group B, (0.87±0.29) in group C and (0.84 ±0.34) in group D (all P>0.05). T/S was (0.88±0.35) in 1-vessel group, (0.85±0.47) in 2-vessel group and (0.89 ±0.26) in multi-vessel group (all P>0.05). Conclusion The telomere length of PWBC is shorter in patients with PCAD, but it is not correlated to stenosis degree and disease extent of coronary artery.%目的：探讨早发冠状动脉粥样硬化性心脏病（冠心病）患者外周血白细胞端粒长度变化。方法选取2010年1月至2011年11月在青岛市立医院心内科住院的冠心病患者80例，男性43例，女性37例，所有患者为病例组。病例组按照Gensini积分分为4组，A组、B组、C组、D组。病例组按照病变范围分为单支组，双支组和多支组。选取同期经冠状动脉造影或冠状动脉CTA检查排除冠心病的76例查体者为对照组。检测两组生化指标、血压以及端粒相对长度（T/S）。结果病例组外周血白细胞端粒长度T/S比值为0.87±0.31，对照组端粒长度T/S比值为1.12±0.25，病例组外周血白细胞端粒相对长度较对照组明显缩短，差异具有统计学意义（P＜0.05）。A组、B组、C组和D组患者外周血白细胞端粒长度T/S比值分别为：0.89±0.41，0.91±0.32，0.87±0.29，0.84±0.34，4组比较差异无统计学意义（P均＞0.05）。单支组、双支组、多支组3组患者外周血白细胞端粒长度T/S比值分别为：0.88±0.35，0.85±0.47，0.89±0.26，3组比较差异无统计学意义（P均＞0.05）。结论早发冠心病患者外周血白细胞端粒相对长度缩短。早发冠心病外周血白细胞端粒相对长度与冠状动脉的狭窄程度及病变范围无明显相关。
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