Objective To study the correlation between L55M polymorphism of paraoxonase-1 (PON1) and coronary heart disease (CHD) in Chinese population. Methods The original studies on the correlation between L55M polymorphism of PON1 and CHD were fully retrieved, eligible studies were included and data was merged. The data was analyzed taking odds ratio (OR) of different genetic models of PON1 and 95%CI as effective indexes. Results There were 6 original studies included into data merging involved 2338 cases (1229 with CHD and 1109 being health control). The results of Meta-analysis showed that the correlation between L55M polymorphism of PON1 and CHD susceptibility had no statistical significance [homozygote comparative model (MM vs. LL):OR=0.57, 95%CI:0.26-1.25, P=0.16, heterozygote comparative model (LM vs. LL):OR=1.46, 95%CI:0.79-2.71, P=0.22, dominant heredity model (MM+LM vs. LL):OR=1.32, 95%CI:0.73-2.38, P=0.35, and recessive heredity model (MM vs. LM+LL):OR=0.56, 95%CI:0.26-1.21, P=0.14]. Conclusion CHD susceptibility is not correlated to L55M polymorphism of PON1 in Chinese population.%目的：研究中国人群对氧磷酯酶1（PON1）基因L55M多态性与冠状动脉粥样硬化性心脏病（冠心病）相关性。方法全面检索关于PON1基因L55M多态性与冠心病关联性的原始研究，纳入符合入选标准研究，并进行数据合并。利用PON1基因的不同的遗传模型OR值及其95%CI作为效应指标进行分析。结果6个原始研究共计2338例对象[其中冠心病患者组1229例，健康对照组1109例]进入最后的数据合并。Meta分析表明PON1基因L55M多态性与冠心病易感性无统计学意义[纯合子比较模型（MM vs. LL）：OR=0.57，95%CI：0.26~1.25，P=0.16；杂合子比较模型（LM vs. LL）：OR=1.46，95%CI：0.79~2.71， P=0.22；显性遗传模型（MM+LM vs. LL）：OR=1.32，95%CI：0.73~2.38，P=0.35；隐性遗传模型（MM vs. LM+LL）：OR=0.56，95%CI：0.26~1.21，P=0.14]。结论中国人群冠心病易感性与PON1基因L55M多态性无关。
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