Objective To compare the influence factors of cardiovascular and cerebrovascular diseases in elderly and middle-aged patients with new-onset type 2 diabetes mellitus (T2DM).Methods The patients (n=470, male 283, female 187 and aged from 40 to 76) were chosen from the Beijing Shijingshan Hospital from Jan. 2012 to Jan. 2016. All patients were divided, according to their ages, into elderly group (n=310, age≥60) and middle-aged group (n=160, 400.05).Conclusion The level of GFR decreases and SBP increases in elderly patients compared with middle-aged patients. The controls of BP and GFR should be strengthened during the comprehensive treatment for down-regulation of blood sugar and blood fat.%目的 比较新发老年2型糖尿病患者与中年患者的心脑血管疾病影响因素.方法 回顾性分析2012年1月~2016年1月于北京市石景山医院住院的新发病的2型糖尿病患者470例的病例资料,其中男性283例,女性187例,年龄范围40~76岁.依据诊断时的年龄分为老年组(310例,≥60岁)和中年组(160例,40岁<年龄<60岁).比较两组患者的血脂、血压、臀围、腰围、体质指数、高敏C反应蛋白(hs-CRP)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、肌酐(Cr)、尿酸(UA)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、胰岛素抵抗指数、胰岛B细胞功能以及肾小球滤过率(eGFR).结果 与中年组比较,老年组肾小球滤过率降低[(129.77±12.29)ml/mim·1.73 m2 vs.(111.18±17.26)ml/mim·1.73 m2],收缩压增高[(125.54±8.77)mmHgvs.(133.5±7.53)mmHg],差异有统计学意义(P均<0.05).老年组与中年组在血脂、臀围、腰围、体质指数、hs-CRP、ALT、AST、UA、Cr、HbA1c、FBG、胰岛素抵抗指数以及胰岛B细胞功能等方面比较,差异均无统计学意义(P均>0.05).结论 新发老年2型糖尿病患者较中年患者肾小球滤过率下降,收缩压升高,在降血糖、降血脂等综合治疗的同时,加强对血压、肾小球滤过率的控制.
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