血栓弹力图对经皮冠状动脉介入治疗术后支架内再狭窄的预测价值

摘要

目的 研究血栓弹力图对经皮冠状动脉介入治疗(PCI)术后支架内再狭窄的预测价值.方法 采用病例对照研究方法 ,选自2013年8月~2014年8月于安阳地区医院诊断为PCI术后1年内支架内再狭窄的患者作为病例组(18例),同时选择PCI术后1年未发生支架内再狭窄的患者作为对照组(50例),观察两组之间血小板聚集抑制率是否存在差异,与PCI术后再狭窄的发生有无统计学关联,是否为其发生的独立危险因素.结果 病例组ADP途径血小板抑制率低于对照组,差异有统计学意义(P<0.05),与PCI术后再狭窄的发生独立相关,OR值为2.063.结论 血小板抑制率与PCI术后支架内再狭窄发生独立相关,ADP途径血小板抑制率不达标为PCI术后患者发生再狭窄的独立危险因素.%Objective To study the predictive value of thrombelastogram (TEG) to in-stent restenosis after percutaneous coronary intervention (PCI).Methods The patients (n=18) with in-stent restenosis within 1 y after PCI (case group) and patients (n=50) without in-stent restenosis within 1 y after PCI (control group) were chosen by applying case-control study method from the Anyang Region Hospital from Aug. 2013 to Aug. 2014. The difference in degree of platelet aggregation inhibition (DPAI) between 2 group, statistical correlation between DPAI and in-stent restenosis after PCI and whether DPAI was independent risk factor of in-stent restenosis or not were observed. Results DPAI in ADP way was lower in case group than that in control group (P<0.05), and it was independently correlated to the incidence of in-stent restenosis after PCI (OR=2.063).Conclusion DPAI is independently correlated to the incidence of in-stent restenosis after PCI, and lower DPAI in ADP way is an independent risk factor of in-stent restenosis after PCI.