镁与心血管疾病死亡率队列研究的Meta分析

摘要

Objective To review systematically the relationship among magnesium intake, serum magnesium and cardiovascular disease mortality (CDM).Methods The databases of PubMed, CNKI, VIP Database and WanFang Database were retrieved with computer for searching the cohort studies on the relationship among magnesium intake, serum magnesium and CDM from database establishment time to Apr. 29, 2016, and meanwhile the references of included studies were retrieved manually. The literature was screened, data was extracted and quality was reviewed independently by 2 reviewers according to inclusion and exclusion criteria, and Stata12.0 software was used for conducting a Meta-analysis.Results There were totally 14 articles included. The results of Meta-analysis showed as follows: ①The difference in CDM had no statistical significance between highest magnesium intake group and lowest magnesium intake group (RR=0.92, 95%CI:0.77~1.10), which indicated that there was no significant correlation between magnesium intake and CDM. ②The difference in CDM had no statistical significance between highest magnesium intake group and lowest magnesium intake group in male subgroup (RR=1.07, 95%CI:0.97~1.19) and highest magnesium intake group and lowest magnesium intake group in female subgroup (RR=0.84, 95%CI:0.61~1.15). ③The difference in CDM had statistical significance between highest serum magnesium group and lowest serum magnesium group (control group), and CDM decreased significantly in highest serum magnesium group (RR=0.74, 95%CI:0.64~0.88).Conclusion The magnesium intake is not correlated to CDM, which has no difference between male group and female group. The level of serum magnesium is negatively correlated to CDM, and in a certain range, the higher the serum magnesium level, the lower the cardiovascular disease mortality.%目的 系统评价镁摄入量和血清镁与心血管疾病死亡率(CDM)之间的关系.方法 计算机检索PubMed、CNKI、维普数据库、万方数据库,查找所有镁摄入量、血清镁与心血管疾病死亡率关系的队列研究,检索时限为从建库至2016年4月29日,同时手工检索纳入研究的参考文献.由2位评价员按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的质量后,采用Stata 12.0软件进行Meta分析.结果 纳入14篇文献,Meta分析显示:①镁摄入量最高组与最低组比较,心血管疾病死亡率相对危险度合并效应量(RR=0.92,95%CI:0.77~1.10),差异无统计学意义,表明镁摄入量与心血管疾病死亡率无明显相关性;②以性别为亚组进行分析,男性组、女性组镁摄入量最高组与最低组心血管疾病死亡率相对危险度合并效应量(男RR=1.07,95%CI:0.97~1.19;女RR=0.84,95%CI:0.61~1.15)分别比较仍无明显统计学差异;③血清镁浓度最高组与最低组(或对照组)相比,差异具有统计学意义,最高组心血管疾病死亡率明显降低(RR=0.74,95%CI:0.64~0.88).结论 镁摄入量与心血管疾病死亡率无明显相关性,在不同性别亚组中均没有明显差异;血清镁浓度与心血管疾病死亡率负相关,在一定的范围内,血清镁浓度越高,心血管疾病死亡率越低.