Objective To study the plasma matrix metalloproteinase-2 (MMP-2) in ST segment elevation myocardial infarction (STEMI) patients to observe the expression of registry of acute coronary events (GRACE) changes in plasma MMP-2 score, effect of MMP-2 on prevention of adverse cardiovascular events. Methods From September 2013 to September 2015, 110STEMI patients (STEMI group) and 100 healthy persons (control group) were selected. Plasma MMP-2 index were measured by ELISA assay. The patient's GRACE score was calculated. General clinical data and MACE events within 6 months after discharge were recorded. Results The level of MMP-2 in STEMI patients was significantly higher than that in the control group [(183.47±46.51) ng/ml vs. (66.26 ±26.73) ng/ml], the difference was statistically significant (P<0.05). In 6 months after discharge from STEMI, 34 patients developed MACE, and MMP-2 and GRACE scores in MACE group were significantly higher than those in non-MACE group (all P<0.05). The area under the curve of MACE predicted by GRACE score and MMP-2 level in 6 months after STEMI were 0.711 (95%CI: 0.565~0.856, P=0.013) and 0.737 (95%CI: 0.601~0.873, P=0.005). Conclusion MMP-2 has some predictive value for the recent occurrence of MACE in STEMI patients.%目的 探索血浆基质金属蛋白酶-2(MMP-2)在ST段抬高性心肌梗死(STEMI)患者中的表达情况,及对近期主要不良心血管事件(MACE)的预测价值.方法 连续入选2013年9月~2015年9月完全符合诊断标准的STEMI患者110例,另选取健康志愿者100例作为对照组.用酶联免疫吸附试验(ELISA)检测血浆MMP-2水平,计算患者出院GRACE评分.记录一般临床资料及出院后6个月内MACE事件发生情况.结果 STEMI患者MMP-2水平较对照组明显升高[(183.47±46.51)ng/ml vs. (66.26± 26.73)ng/ml],差异具有统计学意义(P<0.05);STEMI患者出院后6个月时间内,发生MACE事件者34人,MACE组MMP-2和GRACE评分均高于非MACE组,差异具有统计学意义(P均<0.05);使用受试者工作特征曲线(ROC)分析GRACE评分、MMP-2水平预测STEMI患者6个月内发生MACE的AUC分别为0.711 (95%CI:0.565~0.856,P=0.013)和0.737(95%CI:0.601~0.873,P=0.005).结论 MMP-2对STEMI患者近期发生MACE事件有一定的预测价值.
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