雌激素受体、孕激素受体及增殖细胞核抗原在子宫内膜癌中的表达及意义

摘要

Objective To investigate the expression of ER, PR and PCNA in endometrial adenocarcinoma.Methods Immunohistochemical staining SP method was used to detect the expression of ER, PR and PCNA in 25 cases of normal proliferative endometrium, 25 cases of atypical endometrial hyperplasia, and 40 cases of endometrial adenocarcinoma.Results The expression of ER and PR in norm al proliferative endometrium, atypical endometrial hyperplasia and endometrial adenocarcinoma were decreased gradually( P ＜ 0.05 ).Further study showed that there were associations between expressions of them and cell differentiation in endometrial adenocarcinoma( P ＜ 0.05 ), but not with the surgery pathological stage( P ＞ 0.05 ).The expression of PCNA in norm al proliferative endometrium, atypical endometrial hyperplasia and endometrial adenocarcinoma were increased gradually( P ＜ 0.05 ), and the expression was associate with the cell differentiation in endometrial adenocarcinoma( P ＜0.05 ).Negative correlation was found among ER, PR and PCNA expression( r = -0.361, r = -0.441 respectively, P ＜ 0.05 ).Conclusion Abnormal expression of ER, PR and PCNA may contribute to the pathogenesis and development of the endometrial adenocarcinoma.There expression may provide imformation for clinic in choosing endocrine therapy.%目的 探讨雌激素受体(ER)、孕激素受体(PR)和增殖细胞核抗原(PCNA)在子宫内膜癌中的表达及其临床意义.方法 采用免疫组化SP法检测25例正常增生期子宫内膜、5例子宫内膜不典型增生、40例子宫内膜腺癌组织中ER、PR和PCNA的表达.结果 ER、PR在正常增生期子宫内膜、子宫内膜不典型增生和子宫内膜癌中的表达逐渐降低(P<0.05),进一步分析显示二者表达的高低与子宫内膜癌的组织分化程度有关(P<0.05),而与手术病理分期无关(P>0.05).PCNA在正常增生期子宫内膜、子宫内膜不典型增生和子宫内膜癌中的表达逐渐升高(P<0.05),其表达的高低亦与子宫内膜癌的组织分化程度有关(P<0.05),而与手术病理分期无关(P>0.05).ER、PR与PCNA在子宫内膜癌中的表达呈负相关(分别为r=-0.361,r=-0.441,P<0.05).结论 ER、PR和PCNA的异常表达可能在子宫内膜的恶性转变和细胞分化中发挥着重要的作用,三者的联合检测在指导其内分泌治疗方面有重要的意义.