通心络辅治冠心病心绞痛伴抑郁症状患者的临床观察

摘要

目的：探讨通心络对改善冠心病心绞痛伴抑郁症状患者生活质量和抑郁状态的疗效。方法将冠心病心绞痛伴抑郁障碍的患者72例随机分成2组，每组36例。对照组予常规治疗，观察组在常规治疗基础上再给予通心络胶囊治疗，疗程均为8周，治疗前后应用西雅图心绞痛量表（ SAQ）和汉密尔顿抑郁量表（ HAMD）分别评定患者健康相关的生活质量和抑郁状态。结果与治疗前比较，观察组患者治疗后心绞痛稳定状态、心绞痛发作、治疗满意程度和疾病认知程度均显著改善，对照组心绞痛发作情况、治疗满意度、疾病认知程度均有改善（ P ＜0‡．05或P ＜0．01）。观察组在心绞痛稳定状态和心绞痛发作方面的改善与对照组相比差异有统计学意义（ P ＜0．01）。2组HAMD评分较治疗前均显著下降（ P ＜0．01），且观察组较对照组下降更显著（ P ＜0．01）。2 组的治疗总有效率分别为77．78％和36．11％，差异具有统计学意义（ P ＜0．01）。结论加用通心络治疗较常规治疗能改善冠心病心绞痛伴抑郁症状患者的生活质量及抑郁状态。%Objective To investigate the effect of Tongxinluo capsule on improvement of angina pectoris of coronary heart disease patients with depression symptoms and quality of life of depressive state .Methods Seventy-two cases of patients with angina pectoris of coronary heart disease accompanied with depression were randomly divided into 2 groups, 36 cases in each group.The control group was given conventional treatment , the observation group based on the conventional treatment , also added Tongxinluo capsule treatment, treatment for 8 weeks, before and after the treatment , using the Seattle Angina Questionnaire ( SAQ) and Hamilton Depression Scale ( HAMD) to evaluate patients ’ health related quality of life and depres-sion state.Results Compared with before treatment , patients in the observation group after treatment , angina pectoris condi-tion, the attack of angina pectoris , treatment satisfaction and disease cognitive level were significantly improved , the control group’s attack of angina pectoris , treatment satisfaction, disease recognition degree were improved ( P <0.05 or P <0.01). Angina pectoris condition and angina pectoris improvement in the observation group was significant difference from the control group ( P <0.01).Both of the 2 groups’ HAMD scores were significantly decreased than that before treatment ( P <0.01), and the observation group decreased more significantly than in the control group ( P <0.01).The total effective rate of the 2 group were 77.78%and 36.11%, with significant difference ( P <0.01).Conclusion The quality of life and de-pression condition can be improved with Tongxinluo capsule combined with routine treatment for patients with angina pectoris of coronary heart disease and depression symptoms .