延边地区2型糖尿病患者脂联素SNP+45T/G 基因多态性与颈动脉内膜-中层厚度的相关性研究

摘要

目的 研究APN SNP+45T/G基因多态性与延边地区汉族和朝鲜族群体、T2DM及其动脉硬化间的相关性. 方法 3代非异族通婚当地汉族和朝鲜族入组人群分正常对照(NC)组和T2DM 组为汉族T2DM颈动脉硬化阳性组及阴性组；朝鲜族T2DM颈动脉硬化阳性组及阴性组.采用Taqman 探针法行基因分型. 结果 NC组与T2DM组APN SNP+45T/G基因多态性分布差异有统计学意义(P＜0.05); T2DM组的汉族和朝鲜族APN SNP+45T/G基因多态性分布及等位基因频率差异无统计学意义(P＞0.05)；T2DM动脉硬化阳性组与阴性组APN SNP+ 45基因多态性分布差异无统计学意义(P＞0.05). 结论 APN SNP+45T/G基因多态性在延边地区与T2DM发病相关,但与T2DM颈动脉硬化无相关性；APN SNP+45T/G基因多态性在延边地区T2DM汉族和朝鲜族群体中分布差异无统计学意义(P＞0.05).%Objective To study the correlation of adiponectin gene SNP+45 polymorphism with nationality of Han versus Korean, type 2 diabetes mellitus and carotid atherosclerosis in Yanbian district. Methods Only depth-three endogamy Han and Korean nationality were selected in this study. The subjects included normal control group (Han and Korean nationality), T2DM patients with and without carotid atherosclerosis in Han nationality, and T2DM patients with and without carotid atherosclerosis in Korean nationality. The SNP genotype was confirmed by using Taqman probe. Results There was significant difference in the distribution of adiponectin gene SNP+45 polymorphism between the normal control group and T2DM group. In the T2DM group, there was no significant difference in the distribution of adiponectin gene SNP+45 polymorphism and allele frequency between the Han and Korea nationality. There was no significant difference in the distribution of adiponectin gene SNP+45 polymorphism between T2DM patients with and without carotid atherosclerosis. Conclusion Aadiponectin gene SNP + 45 polymorphism is correlated with type 2 diabetes mellitus in Yanbian district, but it has no correlation with carotid atherosclerosis. There is no difference in distribution of adiponectin gene SNP + 45 polymorphism between Han and Korean T2DM patients in Yanbian district.