Objective To compare of effect of insulin detemir (Det) versus neutral protamine hagedorn (NPI1) combined with oral anti-diabetes drugs (OADs) in treating type 2 diabetes mellitus (T2DM). Methods The 60 T2DM patients divided into two groups were treated with Det + OADs versus NPH + OADs respectively. The comparisons of fasting plasma glucose (FPG), two-hour postprandial plasma glucose (2 hPG), incidence of hypoglycemia, body mass index (BMI), and hemoglobin A1c (HbA1c) between the two groups before versus after treatment were performed to observe the final effect. Results The levels of FPG, 2 hPG, and HbA1c of the two groups were decreased after treatment for 12 weeks, while the decrease in the Det+OADs group was more significant (P<0. 05). The Det+OADs group was superior to the NPH + OADs group in the BMI control (P<0. 05) and less hypoglycemia. Conclusion Comparing with NPH+ OADs, the effect of Det+OADs is better in treating T2DM with less incidence of hypoglycemia and less influence on body weight.%目的 探讨地特胰岛素(Det)对比中性鱼精蛋白锌胰岛素(NPH)联合口服降糖药(OADs)治疗T2DM的疗效和安全性.方法 选择60例T2DM患者分别应用Det和NPH联合OADs治疗,比较两组治疗前后FPG、2 hPG、低血糖事件发生、BMI及HbA1 c变化.结果 两组患者治疗12周后FPG、2 hPG、HbA1 c均较治疗前下降(P＜0.05),但Det组下降更显著(P＜0.05),Det组对BMI控制优于NPH组(P＜0.05),低血糖发生率低.结论 与NPH相比,Det联合OADs治疗T2DM疗效更好,低血糖发生率低,对体重影响小.
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