多乐氟®氟化钠护齿剂与Nd:YAG激光联合治疗牙本质过敏症的临床研究

摘要

Objective The aim of this randomized longitudinal clinical study was to assess the clinical efficacy of Duraphat® dental desensitizing agent, Nd:YAG laser, and its association on dentin hypersensitivity. Methods 96 teeth of 24 volunteers were selected and divided into three groups:G1, Duraphat® Desensitizer (Du-raphat 50mg/ml Dental Suspension, Colgate-Palmolive Company, US);G2, Nd:YAG Laser;G3, Nd:YAG Laser+Duraphat® Desensitizer. The level of sensitivity to pain of each volunteer was analyzed by visual analog scale (VAS) using cold air stimuli and exploratory probe before treatment (pre 01), and at 5 min (post 1), 1 month (post 2), and 6 months (post 3) after treatment. Results No statistically significant differences in VAS score among experimen-tal groups before treatment(P=0.329). After treatment, the reduction VAS scores of Duraphat® group was 72.5%(P<0.001) after 5 min, 38.4%(P<0.05) after 1 month and 13.1%(P>0.05) after 6 months, recorded for G1;the reduction VAS scores of Nd:YAG Laser group was respectively 75.5%, (P<0.001) after 5 min, 45.7%(P<0.001) after 1 month and 21.7%(P<0.05) after 6 months, recorded for G2, and the reduction VAS scores of Duraphat ® combined with Nd:YAG Laser group was respectively 85.9%(P<0.001) after 5 min, 72.0%(P<0.001) after 1 month and 56.3%(P<0.001) after 6 months. Conclusion Both Duraphat® and Nd:YAG Laser were effective in reducing dentinal hypersensitivity, and the combination of the two methods has a better long-lasting effect.%目的：研究多乐氟®氟化钠护齿剂、Nd：YAG激光及其联合应用在牙本质过敏症的临床效果。方法24名患者共96颗患牙，研究对象随机分为3组：多乐氟组、Nd：YAG激光治疗组、多乐氟与Nd：YAG激光联合治疗组，采用数字化疼痛评判法(visual analogue scale, VAS)记录其在治疗前、治疗后5 min、1个月和6个月的牙齿敏感程度，并进行统计学分析。结果各实验组治疗前的VAS评分差异无统计学意义(P=0.329)。与治疗前相比，多乐氟组在治疗后5 min、1个月、6个月VAS评分的疼痛分别降低72.5%(P<0.001)、38.4%(P<0.05)和13.1%(P>0.05)；Nd：YAG激光治疗组疼痛分别降低75.5%(P<0.001)、45.7%(P <0.05)和21.7%(P<0.05)；多乐氟与Nd：YAG激光联合治疗组疼痛分别降低85.9%(P<0.001)、72.0%(P<0.001)和56.3%(P<0.001)。结论多乐氟®氟化钠护齿剂与Nd：YAG激光治疗牙本质敏感症均能产生明显疗效，两者结合应用的远期效果更好。