卡巴胆碱对脓毒症患者胃肠功能障碍治疗的多中心临床研究

摘要

目的 研究卡巴胆碱对脓毒症患者胃肠功能障碍的治疗价值.方法 通过前瞻性、多中心、随机对照临床试验,将入选患者随机分为两组:莫沙必利组(178例)和卡巴胆碱组(286例),分别于入组0 h及用药后24 h、48 h、72 h、7 d或死亡前取血行血浆D-乳酸、内毒素的测定.临床动态监测肠鸣音恢复情况、腹胀、排便、肠管积气积液情况,在上述各时点评定两组患者的胃肠功能评分.结果 与莫沙必利组比较,卡巴胆碱组血浆D-乳酸、内毒素及胃肠功能评分均有显著变化(P<0.05).结论卡巴胆碱能有效改善脓毒症患者的肠道功能,减轻其炎症反应.%Objective To study therapeutical value of carbachol on gastrointestinal dysfunction in patients with sepsis. Methods By a prospective, multicenter, randomized controlled clinical trials, 464 cases will be selected randomly and were divided into two groups respectively. In the group of 0 h, and 24 h, 48 h, 72 h, 7 d after treatment or before death, we test blood plasma endotoxin, plasma D -lactate. At the same time, in order to assess the score of two groups at each time point about gastrointestinal function, we monitored dynamically clinical recovery of bowel sounds, abdominal distension, defecation, intestinal pneumatosis, fluid situation, jvesults Compared with mosapride treatment group, in carbachol treatment group, plasma D - lactate, endotoxin and gastrointestinal function scores changed significantly (P<0.05). Conclusion Carbachol can improve bowel function and reduce the inflammatory response of sepsis patients.