蛋白酶激活受体在ALI/ARDS炎症反应中的作用研究进展

摘要

At present, ALL/ARDS is still complex problems in medical fields, and its pathogenesis is not fully clear. Protease activated receptor ( PAR) is one kind of G protein - coupled receptor subtypes newly discovered, it plays an important regulation in Al_,l/ AROb inflammation reaction by unique activation of intracellular complex signal transduction. This paper briefly describes the PARs structure, activation and inactivation method, intracellular signal transduction and its effects, PARs four subtypes - mediated inflammatory response in ALI/ARDS, and the regulation of inflammatory mediators on the PARs in order to clarify the role of PARs activation in the pathological process of lung%急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)目前仍是困扰医学界的复杂难题,其发病机制尚未完全阐明.蛋白酶激活受体(PARs)是新近发现的一种G蛋白偶联受体亚类,以其独特的激活方式通过细胞内复杂的信号转导,对ALI/ARDS的炎症过程发挥了重要的调节作用.本文简要叙述了PARs的结构、激活和灭活方式、细胞内信号转导及其效应,着重介绍了在ALI/ARDS中PARs四种亚型介导的炎症反应,以及炎性介质对PARs的调控,从而阐明PARs激活在推动肺部炎症病理过程发展中的作用.