胆固醇酯转运蛋白－TaqIB 基因多态性与冠心病发病的相关性研究

摘要

Objective To explore the correlation between CETP-TaqIB gene polymorphism and coronary heart disease ( CHD) .Methods Four hundred coronary arteriongraphy cases in Tianjin Chest Hospital from July, 2012 to March, 2012 were included in this study.If coronary artery diamete stenosis≥50%, we diagnosised coronary heart clisease.Fasting venous blood was collected to test gene CETP-TaqIB, and the corrention between CETP -TaqIB and coronary heart disease was analyzed. Results There was no significant difference on genotype frequencies, alleles frequency distribution between CHD and normal group ( P >0.05 ) .High -density lipoprotein cholesterol, low density lipoprotein cholesterol were associated with CHD; total cholesterol, triglycerides, TaqIB were not associated with CHD.The CETP gene TaqIB polymorphism had no correlation with the severity of coronary heart disease ( P >0.05 ) . Conclusion There was correlation between CETP TaqIB genetyping and CHD patients'high-density lipoprotein cholesterol, low density lipoprotein cholesterol (P<0.05), while had no significant correlation with coronary heart disease incidence and coronary artery triple vessel lesion.Maybe, gene TaqIB is not an independent risk factor for coronary heart disease.%目的：探讨胆固醇酯转运蛋白（ CETP）－TaqIB基因多态性与冠心病（ CHD）发病的相关性。方法选取天津市胸科医院2012－07～2013－03入院行冠状动脉造影检查的符合纳入标准的患者400例，冠状动脉直径狭窄≥50％者为冠心病组（312例），非冠心病组88例，进行血脂水平检测，并抽取空腹静脉血进行CETP－TaqIB基因型检测，分析CETP－TaqIB基因型与冠心病发病的相关性。结果冠心病组基因型分布和等位基因频数分布与非冠心病组比较差异均无统计学意义（ P＞0．05）。 CETP－TaqIB基因多态性与冠状动脉血管病变支数无相关性（ P＞0.05）。高密度脂蛋白（HDL－C）、低密度脂蛋白（LDL－C）与冠心病有相关性（P＜0．05），而总胆固醇（TC）、甘油三酯（TG）、TaqIB基因型与冠心病发病无相关性（P＞0．05）。 CETP－TaqIB基因多态性与冠心病严重程度无相关性（P＞0．05）。结论 CETP－TaqIB基因分型与冠心病患者HDL－C、LDL－C水平有关，TaqIB的基因型与冠心病发病无相关性，与冠心病三支病变严重程度无相关性，TaqIB基因可能不是冠心病发病的独立危险因素。