Objective To analyze the epidemic factors of the outbreak of carbapenems-resis⁃tant Acinetobacter Bauman(AB), and to provide clinical evidence for the prevention and treatment of AB infection in Tumor Hospital. Methods We analyzed the AB distribution patterns, the correlation be⁃tween antibiotics use rate, intensity and drug resistance that in ICU of Xinjiang Tumor Hospital from Jan. 2013 to Dec. 2015 retrospectively. Single factor analysis and non-conditional logistic multivariate regres⁃sion analysis were used to select the independent risk factors for AB infection. Results We collected 157 AB from 2013 to 2015, of which 76 showed MDR-AB, 18 showed XDR-AB, and the drug resistance increased year by year. The rates of AB detection in sputum, urine, blood, drainage and wound secretion were 80.3%, 9.5%, 2.5%, 2.5%, 2.5% respectively. The drug resistance increased with increased ratio and antibiotic use density, while quinolones showed stable trend. Single factor analysis showed the use of sugar cortical hormone and hydrocarbon vinyl antibiotic, mechanical ventilation, in ICU time>7 days and the broad-spectrum antibiotics using time>7 days were risk factors for AB infection. Non-condi⁃tional logistic multivariate regression analysis showed mechanical ventilation, in ICU time>7 days, the use of hydrocarbon vinyl antibiotic, and the broad-spectrum antibiotics using time>7 days were inde⁃pendent risk factors for AB infection. Conclusion AB infection is mainly in the lower respiratory tract in ICU of the Tumor Hospital. The prevalence of drug resistance is positively correlated with the use of broad spectrum antibiotics. Mechanical ventilation, ICU time>7 days, the use of hydrocarbon vinyl anti⁃biotic, and the broadspectrum antibiotics using time>7 days were independent risk factors for AB infec⁃tion. So, carrying clusters of prevention and control measures of AB can prevent the incidence of AB.%目的：通过分析肿瘤医院重症医学科（ICU）内鲍曼不动杆菌（AB）菌株来源分布、耐药性、抗菌药物使用情况和危险因素，探讨2015-08～2015-12耐碳氢酶烯类鲍曼不动杆菌疑似爆发流行发生原因，为防治院内鲍曼不动杆菌的感染提供临床依据。方法采用回顾性方法，分析2013-01～2015-12入住肿瘤医院 ICU 患者感染鲍曼不动杆菌标本来源分布情况；抗菌药物使用率、使用强度和耐药率的相关性；收集鲍曼不动杆菌感染患者的病例资料，采用单因素分析，筛选出鲍曼不动杆菌感染的危险因素；再将P＜0.1的危险因素进行非条件Logistic多元回归分析，筛选出医院感染的独立危险因素。结果2013～2015年ICU 检出鲍曼不动杆菌157株，其中多药耐药76株（48.41%），泛耐药18株（11.46%），耐药性逐年增加，鲍曼不动杆菌在痰液中的检出率为80.3％，尿液中为9.7％，血液、引流液和伤口分泌物中均为2.5％；鲍曼不动杆菌对头孢哌酮钠/舒巴坦和亚胺培南/西司他丁钠的耐药率分别为45.43%和30.67%，耐药性随着使用率和使用强度的增加逐年增加，喹诺酮类使用量稳定，耐药率（41.62%）无明显变化；单因素分析显示，使用糖皮质激素、机械通气、住ICU时间≥7 d、使用碳青霉烯类抗菌素、使用广谱抗菌药物≥7 d是鲍曼不动杆菌院内感染的危险因素（P＜0.1），多因素Logistic回归分析显示，鲍曼不动杆菌院内感染的独立危险因素有机械通气、住 ICU 时间≥7 d、使用碳青霉烯类抗菌药物和使用广谱抗菌药物≥7 d。结论肿瘤医院 ICU 鲍曼不动杆菌检出的主要部位在下呼吸道，耐药率和广谱抗菌药物的使用率、使用强度呈正相关，肿瘤医院 ICU 鲍曼不动杆菌感染的危险因素是机械通气、住 ICU 时间≥7 d、使用碳青霉烯类抗菌药物和使用广谱抗菌药物≥7 d，给予院感集束化防控措施可以ICU内鲍曼不动杆菌感染的发生。
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