他汀类药物引起骨骼肌相关不良反应的临床特点及文献复习

摘要

Objective To analyze the clinical characteristics of skeletal muscle related adverse drug reactions caused by statins . Methods The clinical characteristics of one convalescent with skeletal muscle related adverse drug reactions caused by statins was retrospectively analyzed together with literature review . Results The main clinical manifestations of skeletal muscle related adverse reactions caused by statins were myalgia and muscle weakness with creatase rise . And the occurrence rate was high in people with advanced age , long-term medication , and large dose medication . This suffer-er showed skeletal muscle injury during the medication of statins but only in creatine phosphokinase rise , and creatine kinase gradually decreased with drug withdrawal . Conclusion Skeletal muscle related adverse drug reactions caused by statins are clinically rare but with various clinical manifestations , which should be closely watched in use so as to re-duce the occurrence of adverse reactions .%目的：探讨他汀类药物引起骨骼肌相关不良反应的临床特点。方法结合文献回顾性分析1例服用他汀类药物后发生骨骼肌相关不良反应疗养员的临床特点。结果他汀类药物引起骨骼肌相关不良反应主要表现为肌肉疼痛、无力伴(或)有肌酶升高。高龄、长期服用、大剂量服用的患者发生率更高。本例患者服用他汀类药物过程中出现骨骼肌损害，但仅表现为肌酸磷酸激酶升高，停药后肌酸激酶逐渐降低。结论他汀类药物引起骨骼肌相关不良反应临床罕见，其临床表现多样。在使用过程中应密切关注，减少相关不良反应发生。