轴突生长抑制因子重组疫苗预防免疫减轻阿尔茨海默症模型小鼠行为学损伤

摘要

Objective To study the preventive immunity effects of myelin-azsociated neurite outgrowth inhibitors (NGI) recombinant DNA vaccine on APP/PS1 co-transgenic Alzheimer's model mice.Methods The recombinant DNA vaccine was intramuscularly injected in APP/PS1 co-transgenic mice.Wild type (WT) group, blank group and blank vector group as control.The behavioral tests were examined by the Morris Water Maze.Result The behavioral impairments of vaccine group were significantly approved in Morris Water Maze ( MWM ) ( P ＜ 0.05 ).Conclusion Intramuscularly injected with NGI DNA vaccine attenuated behavioral impairment in a co-transgenic mouse model of Alzheimer's disease.%目的 研究轴突生长抑制因子重组DNA疫苗对转基因阿尔茨海默症小鼠的预防治疗.方法 轴突生长抑制因子重组DNA疫苗肌肉注射APP/PS1双转阿尔茨海默症模型小鼠.设野生对照组、模型对照组、空载体对照组、疫苗组.水迷宫实验检测小鼠行为学差别.结果 疫苗组小鼠在4.5月龄水迷宫实验中学习记忆能力较模型对照及空载体对照组有显著差异(P＜0.05).结论 肌肉注射轴突生长抑制因子DNA重组疫苗能够改善小鼠学习记忆能力.