果蝇模型与心脏衰老遗传机制

摘要

With age , cardiac performance declines progressively and the risk of heart disease , a primary cause of mortality , rises dramatically .As the elderly population continues to increase , it is critical to gain a better understanding of the genetic influences and modulatory factors that impact cardiac aging .As for the human heart , Drosophila heart function also deteriorates with age .Here, In order to better utilize the Drosophila heart model for genetic mechanism studies of cardiac aging , and supply more reliable evidences for molecular-guided diagnostics and therapeutics of age-related heart disease, we sum up the characteristics of cardiac aging of Drosophila in comparative medicine and review genetic factors contributing to cardiac aging , including genes involved in ion exchange , nutrient sensing , and contractile function .These achievements will provide a theoretical basis for molecular guided diagnostics and targeted drug therapied for cardiac aging related diseases , and promote the rapid development of precision medicine of cardiovascular disease .%人类随着年龄的增加，心脏功能逐渐减退，作为主要致死病因的心脏疾病随年龄增加而大幅升高。在老龄化人口不断上涨的今天，深入地了解遗传因素和调节因子在心脏衰老过程中所扮演的角色显得尤为必要。果蝇的心脏像人类一样随着年龄而功能减退，为了更好的利用果蝇心脏模型研究心脏衰老的遗传学机制，为老年性心脏病基于分子靶向的诊断和治疗提供更准确的证据，我们从比较医学的角度总结了果蝇在心脏衰老过程中的特征，特别是遗传因素对其的影响，涉及离子交换、营养敏感和收缩功能相关的基因。这些研究成果将为心脏衰老相关疾病的分子靶向诊断和靶向药物治疗提供理论依据，促进心血管疾病精准医疗的快速发展。