Objective To evaluate the clinical effects of amino acid-based formulae (AAF) combined with rice oil in treating children with persistent diarrhea caused by cow's milk protein allergy (CMPA).Methods We selected 60 infants (6-12 months) with CMPA-induced persistent diarrhea treated in Tianjin Children's Hospital between April 2011 and December 2013 and divided them into control group (n =30) and observation group (n =30) with a random number table.The control group was given AAF treatment,while the observation group was given the combination treatment of AAF + rice oil The two groups were compared in terms of treatment efficiency,period before improvement of stools,antidiarrheal time,early adverse reactions (vomit,abdominal distension),and the period before disappearance of systemic symptoms (frequent crying).Results The effective rate was 89.3％ in the control group and 96.7％ in the observation group,with no statistically significant difference (P =0.267).Adverse reactions disappeared significantly earlier in the observation group than in the control group [abdominal distension:(7.2 ± 1.7) days vs.(9.4 ±2.3) days; vomit:(8.6 ±2.5) days vs.(12.5 ±2.0) days; frequent crying:(8.0 ± 1.6) days vs.(10.0 ± 2.1) days; all P =0.000].Conclusions AAF is the first choice to treat CMPA-induced diarrhea.Early use of AAF in combination with rice oil could achieve better feeding tolerance in infant with CMPA-induced diarrhea.%目的 探讨氨基酸配方营养粉(AAF)联合米油治疗婴儿牛奶蛋白过敏(CMPA)致迁延性腹泻的临床效果.方法 选取天津市儿童医院2011年4月至2013年12月收治的由于CMPA致迁延性腹泻的6 ～12月龄婴儿60例为研究对象,采用随机数字表法分为对照组和观察组,对照组30例患儿给予AAF治疗,观察组30例患儿给予AAF联合米油治疗,以治疗有效率、大便好转时间、止泻时间、早期不良反应(呕吐、腹胀)及全身症状(频繁哭闹)消失时间为观察指标,对比两组患儿的治疗效果.结果 对照组有效率为89.3％,观察组有效率为96.7％,两组有效率比较差异无统计学意义(P=0.267);观察组不良反应消退时间[腹胀(7.2±1.7)d、呕吐(8.6±2.5)d、频繁哭闹(8.0±1.6)d]均早于对照组不良反应消退时间[腹胀(9.4±2.3)d、呕吐(12.5±2.0)d、频繁哭闹(10.0±2.1)d],差异具有统计学意义(P均=0.000).结论 AAF是解决CMPA引起腹泻的最好选择,在早期采用AAF联合米油治疗对CMPA引起的腹泻患儿喂养耐受效果更佳.
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